Mutual causal effects between immune cells and hepatocellular carcinoma: a Mendelian randomization study
Abstract Background Hepatocellular carcinoma (HCC), a malignant tumor that seriously endangering health, has aroused widespread concern in the field of public health. Previous researches have noted the relationships between immune cells and HCC, but the causal relationship was uncertain. Methods In...
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| Format: | Article |
| Language: | English |
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Springer
2025-01-01
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| Series: | Discover Oncology |
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| Online Access: | https://doi.org/10.1007/s12672-025-01785-z |
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| author | Zheng Wang Mengshu Pan Jie Zhu Changhong Liu |
| author_facet | Zheng Wang Mengshu Pan Jie Zhu Changhong Liu |
| author_sort | Zheng Wang |
| collection | DOAJ |
| description | Abstract Background Hepatocellular carcinoma (HCC), a malignant tumor that seriously endangering health, has aroused widespread concern in the field of public health. Previous researches have noted the relationships between immune cells and HCC, but the causal relationship was uncertain. Methods In this study, a bidirectional two sample Mendelian randomization (MR) analysis was utilized to access the causal relationship between immune cell characteristics and HCC. According to the open-access data, we investigated the causal relationship between 731 immune cell characteristics and HCC risk. Results After screening by IVW approach, increased levels of 8 immune traits and reduced levels of 7 immune traits could lead to changes in HCC risk. These 15 immune cells were distributed in the Monocyte (4 cells), Treg panel (4 cells), TBNK (3 cells), Maturation stages of T cell panel (3 cells), and cDC panel (1 cells). Furthermore, HCC was identified to have causal effects on 21 immunophenotypes. Among these immune cells, hepatocarcinogenesis had the greatest impact on CD4 on EM CD4 + and CD33 on Mo MDSC. Conclusions This study enhances our comprehension of the interaction between immune cells and HCC risk, furnishing novel avenues to explore the mechanisms of HCC. |
| format | Article |
| id | doaj-art-a96236705bbf4afabe6721c776124ce7 |
| institution | Kabale University |
| issn | 2730-6011 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Springer |
| record_format | Article |
| series | Discover Oncology |
| spelling | doaj-art-a96236705bbf4afabe6721c776124ce72025-01-19T12:29:08ZengSpringerDiscover Oncology2730-60112025-01-0116111210.1007/s12672-025-01785-zMutual causal effects between immune cells and hepatocellular carcinoma: a Mendelian randomization studyZheng Wang0Mengshu Pan1Jie Zhu2Changhong Liu3Department of Critical Care Medicine, Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityPrimary Care Department, Second Affiliated Hospital of Anhui Medical UniversityDepartment of Infectious Disease, Second Affiliated Hospital of Anhui Medical UniversityDepartment of Gastroenterology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan HospitalAbstract Background Hepatocellular carcinoma (HCC), a malignant tumor that seriously endangering health, has aroused widespread concern in the field of public health. Previous researches have noted the relationships between immune cells and HCC, but the causal relationship was uncertain. Methods In this study, a bidirectional two sample Mendelian randomization (MR) analysis was utilized to access the causal relationship between immune cell characteristics and HCC. According to the open-access data, we investigated the causal relationship between 731 immune cell characteristics and HCC risk. Results After screening by IVW approach, increased levels of 8 immune traits and reduced levels of 7 immune traits could lead to changes in HCC risk. These 15 immune cells were distributed in the Monocyte (4 cells), Treg panel (4 cells), TBNK (3 cells), Maturation stages of T cell panel (3 cells), and cDC panel (1 cells). Furthermore, HCC was identified to have causal effects on 21 immunophenotypes. Among these immune cells, hepatocarcinogenesis had the greatest impact on CD4 on EM CD4 + and CD33 on Mo MDSC. Conclusions This study enhances our comprehension of the interaction between immune cells and HCC risk, furnishing novel avenues to explore the mechanisms of HCC.https://doi.org/10.1007/s12672-025-01785-zImmune cellHepatocellular carcinomaMendelian randomizationImmunophenotypes |
| spellingShingle | Zheng Wang Mengshu Pan Jie Zhu Changhong Liu Mutual causal effects between immune cells and hepatocellular carcinoma: a Mendelian randomization study Discover Oncology Immune cell Hepatocellular carcinoma Mendelian randomization Immunophenotypes |
| title | Mutual causal effects between immune cells and hepatocellular carcinoma: a Mendelian randomization study |
| title_full | Mutual causal effects between immune cells and hepatocellular carcinoma: a Mendelian randomization study |
| title_fullStr | Mutual causal effects between immune cells and hepatocellular carcinoma: a Mendelian randomization study |
| title_full_unstemmed | Mutual causal effects between immune cells and hepatocellular carcinoma: a Mendelian randomization study |
| title_short | Mutual causal effects between immune cells and hepatocellular carcinoma: a Mendelian randomization study |
| title_sort | mutual causal effects between immune cells and hepatocellular carcinoma a mendelian randomization study |
| topic | Immune cell Hepatocellular carcinoma Mendelian randomization Immunophenotypes |
| url | https://doi.org/10.1007/s12672-025-01785-z |
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