Robust and reproducible human intestinal organoid-derived monolayer model for analyzing drug absorption

Robust and reproducible human intestinal organoid-derived monolayer model for analyzing drug absorption

Abstract Predicting the absorption of orally administered drugs is crucial to drug development. Current in vitro models lack physiological relevance, robustness, and reproducibility, thus hindering reliable predictions. In this study, we developed a reproducible and robust culture method to generate...

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Main Authors: Kai Tanaka, Tatsuki Mochizuki, Shogo Baba, Shigeto Kawai, Kiyotaka Nakano, Tatsuhiko Tachibana, Kohsuke Uchimura, Atsuhiko Kato, Takashi Miyayama, Tomohito Yamaguchi, Hiroshi Nishihara, Kimio Terao, Yasutaka Kato
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Scientific Reports
Subjects:
Drug absorption modeling
Human intestinal organoids
Pharmacokinetic prediction
In vitro drug screening
Precision drug development
Online Access:https://doi.org/10.1038/s41598-025-95823-z
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https://doi.org/10.1038/s41598-025-95823-z

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