Influence of TMPRSS6 genotype on iron status parameters in stable COPD patients
Background: The SNP rs855791 has been linked to increased hepcidin levels, variations in serum iron, transferrin saturation and red blood cell indices. Our goal was to determine the prevalence of this polymorphism among COPD patients and to assess its impact on iron status parameters in patients wit...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Society of Medical Biochemists of Serbia, Belgrade
2025-01-01
|
| Series: | Journal of Medical Biochemistry |
| Subjects: | |
| Online Access: | https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2025/1452-82582501129T.pdf |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832096607652282368 |
|---|---|
| author | Trtica Marko Novaković Ivana Dopsaj Violeta Milenković Branislava Janković Jelena Dimić-Janjić Sanja Dopuđa-Pantić Vesna Martinović Jelena Jovičić Snežana |
| author_facet | Trtica Marko Novaković Ivana Dopsaj Violeta Milenković Branislava Janković Jelena Dimić-Janjić Sanja Dopuđa-Pantić Vesna Martinović Jelena Jovičić Snežana |
| author_sort | Trtica Marko |
| collection | DOAJ |
| description | Background: The SNP rs855791 has been linked to increased hepcidin levels, variations in serum iron, transferrin saturation and red blood cell indices. Our goal was to determine the prevalence of this polymorphism among COPD patients and to assess its impact on iron status parameters in patients with stable COPD. Methods: We analysed iron status parameters and genetic data from 29 COPD patients with wild-type genotype (WT group) and 65 COPD patients with either homozygous or heterozygous genotype (HH group). Additionally, the prevalence of SNP rs855791 was assessed in 192 volunteers. Results: The frequency distribution of SNP rs855791 was comparable between the COPD patients and control subjects (p=0.791). Iron status parameters were within their respective reference values and showed neither statistically nor clinically significant difference between the WT and HH group of COPD patients. However, after excluding patients with (sub)clinical vitamin B12 deficiency and/or hypoxemia, WT group of patients exhibited significantly lower erythropoietin levels (p=0.015). The area under the curve for erythropoietin was 0.688 (95% CI: 0.545-0.830, p=0.015), with an optimal cut-off of 9.74, sensitivity of 61.2% (95% CI: 58.1-64.3) and specificity of 65.0% (95% CI: 61.8-68.3).Conclusions: Iron status parameters do not differ between WT and HH groups of stable COPD patients. Statistical but not clinical difference in EPO levels was observed in a subgroup of patients. In addition to promoting erythropoiesis, EPO may regulate hepcidin levels and thus influence the development of iron deficiency and/or anaemia. Also, EPO's direct effect on immune cells and down-regulation of inflammatory reactions should be considered in this context. |
| format | Article |
| id | doaj-art-a91a13a874b14a2789debdd86272296b |
| institution | Kabale University |
| issn | 1452-8258 1452-8266 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Society of Medical Biochemists of Serbia, Belgrade |
| record_format | Article |
| series | Journal of Medical Biochemistry |
| spelling | doaj-art-a91a13a874b14a2789debdd86272296b2025-02-05T13:11:23ZengSociety of Medical Biochemists of Serbia, BelgradeJournal of Medical Biochemistry1452-82581452-82662025-01-0144112914010.5937/jomb0-529961452-82582501129TInfluence of TMPRSS6 genotype on iron status parameters in stable COPD patientsTrtica Marko0Novaković Ivana1https://orcid.org/0000-0003-0202-0673Dopsaj Violeta2https://orcid.org/0000-0001-8310-6254Milenković Branislava3https://orcid.org/0000-0002-0767-6869Janković Jelena4https://orcid.org/0000-0001-8529-8624Dimić-Janjić Sanja5https://orcid.org/0000-0001-9989-3862Dopuđa-Pantić Vesna6Martinović Jelena7Jovičić Snežana8https://orcid.org/0000-0002-6878-8645University of Belgrade, Faculty of Pharmacy, Department of Medical Biochemistry, Belgrade, SerbiaUniversity of Belgrade, Faculty of Medicine, Institute of Human Genetics, Belgrade, SerbiaUniversity of Belgrade, Faculty of Pharmacy, Department of Medical Biochemistry, Belgrade, SerbiaUniversity of Belgrade, Faculty of Medicine, Belgrade, SerbiaUniversity of Belgrade, Faculty of Medicine, Belgrade, SerbiaUniversity of Belgrade, Faculty of Medicine, Belgrade, SerbiaZvezdara Clinical Hospital Center, Clinical Department of Pulmonology and Allergology with Immunology, Belgrade, SerbiaSante Biohemija, Belgrade, SerbiaUniversity of Belgrade, Faculty of Pharmacy, Department of Medical Biochemistry, Belgrade, SerbiaBackground: The SNP rs855791 has been linked to increased hepcidin levels, variations in serum iron, transferrin saturation and red blood cell indices. Our goal was to determine the prevalence of this polymorphism among COPD patients and to assess its impact on iron status parameters in patients with stable COPD. Methods: We analysed iron status parameters and genetic data from 29 COPD patients with wild-type genotype (WT group) and 65 COPD patients with either homozygous or heterozygous genotype (HH group). Additionally, the prevalence of SNP rs855791 was assessed in 192 volunteers. Results: The frequency distribution of SNP rs855791 was comparable between the COPD patients and control subjects (p=0.791). Iron status parameters were within their respective reference values and showed neither statistically nor clinically significant difference between the WT and HH group of COPD patients. However, after excluding patients with (sub)clinical vitamin B12 deficiency and/or hypoxemia, WT group of patients exhibited significantly lower erythropoietin levels (p=0.015). The area under the curve for erythropoietin was 0.688 (95% CI: 0.545-0.830, p=0.015), with an optimal cut-off of 9.74, sensitivity of 61.2% (95% CI: 58.1-64.3) and specificity of 65.0% (95% CI: 61.8-68.3).Conclusions: Iron status parameters do not differ between WT and HH groups of stable COPD patients. Statistical but not clinical difference in EPO levels was observed in a subgroup of patients. In addition to promoting erythropoiesis, EPO may regulate hepcidin levels and thus influence the development of iron deficiency and/or anaemia. Also, EPO's direct effect on immune cells and down-regulation of inflammatory reactions should be considered in this context.https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2025/1452-82582501129T.pdfb12 deficiencycopderythropoietinhepcidiniron status parameterstmprss6 gene polymorphism |
| spellingShingle | Trtica Marko Novaković Ivana Dopsaj Violeta Milenković Branislava Janković Jelena Dimić-Janjić Sanja Dopuđa-Pantić Vesna Martinović Jelena Jovičić Snežana Influence of TMPRSS6 genotype on iron status parameters in stable COPD patients Journal of Medical Biochemistry b12 deficiency copd erythropoietin hepcidin iron status parameters tmprss6 gene polymorphism |
| title | Influence of TMPRSS6 genotype on iron status parameters in stable COPD patients |
| title_full | Influence of TMPRSS6 genotype on iron status parameters in stable COPD patients |
| title_fullStr | Influence of TMPRSS6 genotype on iron status parameters in stable COPD patients |
| title_full_unstemmed | Influence of TMPRSS6 genotype on iron status parameters in stable COPD patients |
| title_short | Influence of TMPRSS6 genotype on iron status parameters in stable COPD patients |
| title_sort | influence of tmprss6 genotype on iron status parameters in stable copd patients |
| topic | b12 deficiency copd erythropoietin hepcidin iron status parameters tmprss6 gene polymorphism |
| url | https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2025/1452-82582501129T.pdf |
| work_keys_str_mv | AT trticamarko influenceoftmprss6genotypeonironstatusparametersinstablecopdpatients AT novakovicivana influenceoftmprss6genotypeonironstatusparametersinstablecopdpatients AT dopsajvioleta influenceoftmprss6genotypeonironstatusparametersinstablecopdpatients AT milenkovicbranislava influenceoftmprss6genotypeonironstatusparametersinstablecopdpatients AT jankovicjelena influenceoftmprss6genotypeonironstatusparametersinstablecopdpatients AT dimicjanjicsanja influenceoftmprss6genotypeonironstatusparametersinstablecopdpatients AT dopuđapanticvesna influenceoftmprss6genotypeonironstatusparametersinstablecopdpatients AT martinovicjelena influenceoftmprss6genotypeonironstatusparametersinstablecopdpatients AT jovicicsnezana influenceoftmprss6genotypeonironstatusparametersinstablecopdpatients |