Effects of Eleclazine (GS6615) on the proarrhythmic electrophysiological changes induced by myocardial stretch

Effects of Eleclazine (GS6615) on the proarrhythmic electrophysiological changes induced by myocardial stretch

PurposeMyocardial stretch is a proarrhythmic factor. Eleclazine (GS6615) is a late sodium current (INaL) inhibitor that has shown protective effects against arrhythmias in various experimental models. Data on its effects during myocardial stretch are lacking. The aim of this study was to investigate...

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Bibliographic Details
Main Authors: Francisco J. Chorro, Luis Such-Miquel, Samuel Cuñat, Oscar Arias-Mutis, Patricia Genovés, Manuel Zarzoso, Antonio Alberola, Luis Such-Belenguer, Irene Del Canto
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Physiology
Subjects:
arrhythmias
myocardial stretch
Eleclazine (GS6615)
ventricular fibrillation
cardiac mapping
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2025.1525836/full
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https://www.frontiersin.org/articles/10.3389/fphys.2025.1525836/full

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