Mitsugumin 53 drives stem cell differentiation easing intestinal injury and inflammation

Mitsugumin 53 drives stem cell differentiation easing intestinal injury and inflammation

Abstract Emerging evidence suggests that priming intestinal stem cells (ISCs) towards secretory progenitor cells is beneficial for maintaining gut homeostasis against inflammatory bowel disease (IBD). However, the mechanism driving such biased lineage commitment remains elusive. Here we show that MG...

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Main Authors: Yumeng Pei, Meng Fang, Hong-Kun Wu, Qionghua Cui, Li Quan, Xiaochuan Li, Keyi Zhang, Peng Xie, Peng Jiang, Yuan Liu, Meimei Huang, Fengxiang Lv, Xiaomin Hu, Ye-Guang Chen, Xinli Hu, Rui-Ping Xiao
Format: Article
Language:English
Published: Nature Publishing Group 2025-06-01
Series:Signal Transduction and Targeted Therapy
Online Access:https://doi.org/10.1038/s41392-025-02268-x
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https://doi.org/10.1038/s41392-025-02268-x

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