Establishing metrics of clinically meaningful change for treating knee osteoarthritis with a combination of autologous orthobiologics

Establishing metrics of clinically meaningful change for treating knee osteoarthritis with a combination of autologous orthobiologics

Abstract Autologous bone marrow concentrate (BMC), platelet-rich plasma (PRP), and platelet lysate (PL) have emerged as promising orthobiologic treatment options for knee osteoarthritis (OA). The present observational study reports minimal clinically important difference (MCID) and substantial clini...

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Bibliographic Details
Main Authors: Christopher J. Centeno, James R. Ghattas, Ehren Dodson, Neven J. Steinmetz, Matthew B. Murphy, Dustin R. Berger
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:Scientific Reports
Subjects:
Bone marrow concentrate
Knee osteoarthritis
Minimal clinically important difference
Platelet lysate
Platelet rich plasma
Substantial clinical benefit
Online Access:https://doi.org/10.1038/s41598-025-91972-3
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https://doi.org/10.1038/s41598-025-91972-3

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