Persistent hepatocyte secretory failure in lopinavir/ritonavir related to drug-induced liver injury: a case report
Lopinavir/ritonavir, an anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) drug, may be associated with the development of liver injury. In this paper, we reported an elderly female patient with drug-induced liver injury secondary to lopinavir/ritonavir, which was evaluated for their...
Saved in:
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-02-01
|
| Series: | Frontiers in Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2025.1492002/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832087243630575616 |
|---|---|
| author | Yue Sun Ran Wang Cai'e Wang Xiaodong Shao Xiaojie Zheng Hui Li Yingkai Chi Baocheng Deng Yiling Li Shenghao Jin Xingshun Qi |
| author_facet | Yue Sun Ran Wang Cai'e Wang Xiaodong Shao Xiaojie Zheng Hui Li Yingkai Chi Baocheng Deng Yiling Li Shenghao Jin Xingshun Qi |
| author_sort | Yue Sun |
| collection | DOAJ |
| description | Lopinavir/ritonavir, an anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) drug, may be associated with the development of liver injury. In this paper, we reported an elderly female patient with drug-induced liver injury secondary to lopinavir/ritonavir, which was evaluated for their causality using the updated Roussel Uclaf Causality Assessment Method (RUCAM) of 2016. She had a RUCAM score of 8 which was equivalent to a probable causality grading. Her clinical course was complicated by persistent hepatocyte secretion failure (PHSF), followed by septic shock and SARS-CoV-2 re-infection during her hospitalization. Her response to any medical intervention, including ursodeoxycholic acid, glutathione, methylprednisolone sodium succinate, rifampicin, artificial liver support, and endoscopic nasobiliary drainage (ENBD) was very poor, and her family members refused liver transplantation. Finally, she died. In summary, this case suggests the possibility that lopinavir/ritonavir can cause DILI and even PHSF in our clinical practice. |
| format | Article |
| id | doaj-art-a83dcd2ffebe4b83896908dd08257ebe |
| institution | Kabale University |
| issn | 2296-858X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj-art-a83dcd2ffebe4b83896908dd08257ebe2025-02-06T07:09:06ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2025-02-011210.3389/fmed.2025.14920021492002Persistent hepatocyte secretory failure in lopinavir/ritonavir related to drug-induced liver injury: a case reportYue Sun0Ran Wang1Cai'e Wang2Xiaodong Shao3Xiaojie Zheng4Hui Li5Yingkai Chi6Baocheng Deng7Yiling Li8Shenghao Jin9Xingshun Qi10Department of Gastroenterology, General Hospital of Northern Theater Command (Teaching Hospital of Dalian Medical University), Shenyang, ChinaDepartment of Gastroenterology, General Hospital of Northern Theater Command, Shenyang, ChinaDepartment of Gastroenterology, General Hospital of Northern Theater Command (Teaching Hospital of Shenyang Pharmaceutical University), Shenyang, ChinaDepartment of Gastroenterology, General Hospital of Northern Theater Command, Shenyang, ChinaDepartment of Gastroenterology, The Second Affiliated Hospital of Shenyang Medical College, Shenyang, ChinaDepartment of Gastroenterology, General Hospital of Northern Theater Command (Teaching Hospital of Shenyang Pharmaceutical University), Shenyang, ChinaDepartment of Pathology, General Hospital of Northern Theater Command, Shenyang, ChinaDepartment of Infectious Diseases, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, ChinaDepartment of Gastroenterology, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, ChinaSchool of Clinical Medicine, China Medical University, Shenyang, Liaoning, ChinaDepartment of Gastroenterology, General Hospital of Northern Theater Command (Teaching Hospital of Dalian Medical University), Shenyang, ChinaLopinavir/ritonavir, an anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) drug, may be associated with the development of liver injury. In this paper, we reported an elderly female patient with drug-induced liver injury secondary to lopinavir/ritonavir, which was evaluated for their causality using the updated Roussel Uclaf Causality Assessment Method (RUCAM) of 2016. She had a RUCAM score of 8 which was equivalent to a probable causality grading. Her clinical course was complicated by persistent hepatocyte secretion failure (PHSF), followed by septic shock and SARS-CoV-2 re-infection during her hospitalization. Her response to any medical intervention, including ursodeoxycholic acid, glutathione, methylprednisolone sodium succinate, rifampicin, artificial liver support, and endoscopic nasobiliary drainage (ENBD) was very poor, and her family members refused liver transplantation. Finally, she died. In summary, this case suggests the possibility that lopinavir/ritonavir can cause DILI and even PHSF in our clinical practice.https://www.frontiersin.org/articles/10.3389/fmed.2025.1492002/fullcase reportdrug-induced liver injurypersistent hepatocyte secretion failurelopinavir/ritonavirupdated RUCAM |
| spellingShingle | Yue Sun Ran Wang Cai'e Wang Xiaodong Shao Xiaojie Zheng Hui Li Yingkai Chi Baocheng Deng Yiling Li Shenghao Jin Xingshun Qi Persistent hepatocyte secretory failure in lopinavir/ritonavir related to drug-induced liver injury: a case report Frontiers in Medicine case report drug-induced liver injury persistent hepatocyte secretion failure lopinavir/ritonavir updated RUCAM |
| title | Persistent hepatocyte secretory failure in lopinavir/ritonavir related to drug-induced liver injury: a case report |
| title_full | Persistent hepatocyte secretory failure in lopinavir/ritonavir related to drug-induced liver injury: a case report |
| title_fullStr | Persistent hepatocyte secretory failure in lopinavir/ritonavir related to drug-induced liver injury: a case report |
| title_full_unstemmed | Persistent hepatocyte secretory failure in lopinavir/ritonavir related to drug-induced liver injury: a case report |
| title_short | Persistent hepatocyte secretory failure in lopinavir/ritonavir related to drug-induced liver injury: a case report |
| title_sort | persistent hepatocyte secretory failure in lopinavir ritonavir related to drug induced liver injury a case report |
| topic | case report drug-induced liver injury persistent hepatocyte secretion failure lopinavir/ritonavir updated RUCAM |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2025.1492002/full |
| work_keys_str_mv | AT yuesun persistenthepatocytesecretoryfailureinlopinavirritonavirrelatedtodruginducedliverinjuryacasereport AT ranwang persistenthepatocytesecretoryfailureinlopinavirritonavirrelatedtodruginducedliverinjuryacasereport AT caiewang persistenthepatocytesecretoryfailureinlopinavirritonavirrelatedtodruginducedliverinjuryacasereport AT xiaodongshao persistenthepatocytesecretoryfailureinlopinavirritonavirrelatedtodruginducedliverinjuryacasereport AT xiaojiezheng persistenthepatocytesecretoryfailureinlopinavirritonavirrelatedtodruginducedliverinjuryacasereport AT huili persistenthepatocytesecretoryfailureinlopinavirritonavirrelatedtodruginducedliverinjuryacasereport AT yingkaichi persistenthepatocytesecretoryfailureinlopinavirritonavirrelatedtodruginducedliverinjuryacasereport AT baochengdeng persistenthepatocytesecretoryfailureinlopinavirritonavirrelatedtodruginducedliverinjuryacasereport AT yilingli persistenthepatocytesecretoryfailureinlopinavirritonavirrelatedtodruginducedliverinjuryacasereport AT shenghaojin persistenthepatocytesecretoryfailureinlopinavirritonavirrelatedtodruginducedliverinjuryacasereport AT xingshunqi persistenthepatocytesecretoryfailureinlopinavirritonavirrelatedtodruginducedliverinjuryacasereport |