Spinal Cord Pathology in Alpha-Synuclein Transgenic Mice
Accumulation of α-synuclein is observed in neurodegenerative diseases like Parkinson's disease and Multiple System Atrophy. In previous studies with transgenic C57BL/6 mice overexpressing α-synuclein carrying the mutations A53T and A30P found in Parkinson's disease or with a parkin-null ba...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | Parkinson's Disease |
| Online Access: | http://dx.doi.org/10.4061/2010/375462 |
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| author | Sonja Mendritzki Saskia Schmidt Teresa Sczepan Xin-Ran Zhu Daniel Segelcke Hermann Lübbert |
| author_facet | Sonja Mendritzki Saskia Schmidt Teresa Sczepan Xin-Ran Zhu Daniel Segelcke Hermann Lübbert |
| author_sort | Sonja Mendritzki |
| collection | DOAJ |
| description | Accumulation of α-synuclein is observed in neurodegenerative diseases like Parkinson's disease and Multiple System Atrophy. In previous studies with transgenic C57BL/6 mice overexpressing α-synuclein carrying the mutations A53T and A30P found in Parkinson's disease or with a parkin-null background, we reported severe mitochondrial impairments in neurons and to a larger extent in glial cells of the mesencephalon. Neuron death was not observed in the brain. Here we show that the mice show severe motor impairments in behavioral tests. In addition, these mice exhibit astrocytic cell death in the spinal cord, accompanied by extensive gliosis and microglial activation. This is shown by cell death staining and immunohistochemistry. Ultrastructural analyses revealed severe mitochondrial impairments not only in astrocytes, but also in oligodendrocytes and, to a small extent, in neurons.
Thus, the transgenic mice show a profound pathology in glial cells of the spinal cord. |
| format | Article |
| id | doaj-art-a81c9e5f933641ccb5ed9fde9182fe38 |
| institution | Kabale University |
| issn | 2042-0080 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Parkinson's Disease |
| spelling | doaj-art-a81c9e5f933641ccb5ed9fde9182fe382025-02-03T06:05:30ZengWileyParkinson's Disease2042-00802010-01-01201010.4061/2010/375462375462Spinal Cord Pathology in Alpha-Synuclein Transgenic MiceSonja Mendritzki0Saskia Schmidt1Teresa Sczepan2Xin-Ran Zhu3Daniel Segelcke4Hermann Lübbert5Department of Animal Physiology, Biology, and Biotechnology, Ruhr-University Bochum, ND/5131, D-44780 Bochum, GermanyDepartment of Animal Physiology, Biology, and Biotechnology, Ruhr-University Bochum, ND/5131, D-44780 Bochum, GermanyDepartment of Animal Physiology, Biology, and Biotechnology, Ruhr-University Bochum, ND/5131, D-44780 Bochum, GermanyDepartment of Animal Physiology, Biology, and Biotechnology, Ruhr-University Bochum, ND/5131, D-44780 Bochum, GermanyDepartment of Animal Physiology, Biology, and Biotechnology, Ruhr-University Bochum, ND/5131, D-44780 Bochum, GermanyDepartment of Animal Physiology, Biology, and Biotechnology, Ruhr-University Bochum, ND/5131, D-44780 Bochum, GermanyAccumulation of α-synuclein is observed in neurodegenerative diseases like Parkinson's disease and Multiple System Atrophy. In previous studies with transgenic C57BL/6 mice overexpressing α-synuclein carrying the mutations A53T and A30P found in Parkinson's disease or with a parkin-null background, we reported severe mitochondrial impairments in neurons and to a larger extent in glial cells of the mesencephalon. Neuron death was not observed in the brain. Here we show that the mice show severe motor impairments in behavioral tests. In addition, these mice exhibit astrocytic cell death in the spinal cord, accompanied by extensive gliosis and microglial activation. This is shown by cell death staining and immunohistochemistry. Ultrastructural analyses revealed severe mitochondrial impairments not only in astrocytes, but also in oligodendrocytes and, to a small extent, in neurons. Thus, the transgenic mice show a profound pathology in glial cells of the spinal cord.http://dx.doi.org/10.4061/2010/375462 |
| spellingShingle | Sonja Mendritzki Saskia Schmidt Teresa Sczepan Xin-Ran Zhu Daniel Segelcke Hermann Lübbert Spinal Cord Pathology in Alpha-Synuclein Transgenic Mice Parkinson's Disease |
| title | Spinal Cord Pathology in Alpha-Synuclein Transgenic Mice |
| title_full | Spinal Cord Pathology in Alpha-Synuclein Transgenic Mice |
| title_fullStr | Spinal Cord Pathology in Alpha-Synuclein Transgenic Mice |
| title_full_unstemmed | Spinal Cord Pathology in Alpha-Synuclein Transgenic Mice |
| title_short | Spinal Cord Pathology in Alpha-Synuclein Transgenic Mice |
| title_sort | spinal cord pathology in alpha synuclein transgenic mice |
| url | http://dx.doi.org/10.4061/2010/375462 |
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