Microglial depletion and repopulation differentially modulate sleep and inflammation in a mouse model of traumatic brain injury

Traumatic brain injury (TBI) causes persistent sleep disturbances, leading to long-term neurological consequences and reduced quality of life. We hypothesized that microglial depletion via PLX5622 (PLX), a colony-stimulating factor 1 receptor (CSFR1R) inhibitor, would exacerbate sleep disturbances a...

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Bibliographic Details
Main Authors: Katherine R. Giordano, Tabitha R.F. Green, Mark R. Opp, Rachel K. Rowe
Format: Article
Language:English
Published: Elsevier 2025-05-01
Series:Neurobiology of Sleep and Circadian Rhythms
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Online Access:http://www.sciencedirect.com/science/article/pii/S2451994425000045
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