Conserved role of spike S2 domain N-glycosylation across betacoronaviruses

Abstract Besides acting as an immunological shield, the N-glycans of SARS-CoV-2 are also critical for viral life cycle. As the S2 subunit of spike is highly conserved across betacoronaviruses, we determined the functional significance of the five ‘stem N-glycans’ located in S2 between N1098-N1194. S...

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Bibliographic Details
Main Authors: Qi Yang, Anju Kelkar, Balaji Manicassamy, Sriram Neelamegham
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:npj Viruses
Online Access:https://doi.org/10.1038/s44298-024-00085-7
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