Analgesic Mechanism of Sinomenine against Chronic Pain
Purified from the roots of the plant Sinomenium acutum, sinomenine is traditionally used in China and Japan for treating rheumatism and arthritis. Previously, we have demonstrated that sinomenine possessed a broad analgesic spectrum in various chronic pain animal models and repeated administration o...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Pain Research and Management |
| Online Access: | http://dx.doi.org/10.1155/2020/1876862 |
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| author | Wei Jiang Weiming Fan Tianle Gao Tao Li Zhenming Yin Huihui Guo Lulu Wang Yanxing Han Jian-Dong Jiang |
| author_facet | Wei Jiang Weiming Fan Tianle Gao Tao Li Zhenming Yin Huihui Guo Lulu Wang Yanxing Han Jian-Dong Jiang |
| author_sort | Wei Jiang |
| collection | DOAJ |
| description | Purified from the roots of the plant Sinomenium acutum, sinomenine is traditionally used in China and Japan for treating rheumatism and arthritis. Previously, we have demonstrated that sinomenine possessed a broad analgesic spectrum in various chronic pain animal models and repeated administration of sinomenine did not generate tolerance. In this review article, we discussed sinomenine’s analgesic mechanism with focus on its role on immune regulation and neuroimmune interaction. Sinomenine has distinct immunoregulative properties, in which glutamate, adenosine triphosphate, nitric oxide, and proinflammatory cytokines are thought to be involved. Sinomenine may alter the unbalanced neuroimmune interaction and inhibit neuroinflammation, oxidative stress, and central sensitization in chronic pain states. In conclusion, sinomenine has promising potential for chronic pain management in different clinical settings. |
| format | Article |
| id | doaj-art-a7f1d2d9a7634c9ab517723c440b8fce |
| institution | Kabale University |
| issn | 1203-6765 1918-1523 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Pain Research and Management |
| spelling | doaj-art-a7f1d2d9a7634c9ab517723c440b8fce2025-02-03T01:01:31ZengWileyPain Research and Management1203-67651918-15232020-01-01202010.1155/2020/18768621876862Analgesic Mechanism of Sinomenine against Chronic PainWei Jiang0Weiming Fan1Tianle Gao2Tao Li3Zhenming Yin4Huihui Guo5Lulu Wang6Yanxing Han7Jian-Dong Jiang8Zhejiang Zhenyuan Pharmaceutical Co., Ltd, 1015 West Shengli Road, Shaoxing, Zhejiang 312000, ChinaZhejiang Zhenyuan Pharmaceutical Co., Ltd, 1015 West Shengli Road, Shaoxing, Zhejiang 312000, ChinaState Key Laboratory of Bioactive Substances and Function of Natural Medicine, Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing 100050, ChinaBeijing Key Laboratory of Traditional Chinese Medicine Basic Research on Prevention and Treatment of Major Diseases, Experimental Research Center, China Academy of Chinese Medical Sciences, Beijing 100700, ChinaState Key Laboratory of Bioactive Substances and Function of Natural Medicine, Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing 100050, ChinaState Key Laboratory of Bioactive Substances and Function of Natural Medicine, Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing 100050, ChinaState Key Laboratory of Bioactive Substances and Function of Natural Medicine, Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing 100050, ChinaState Key Laboratory of Bioactive Substances and Function of Natural Medicine, Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing 100050, ChinaState Key Laboratory of Bioactive Substances and Function of Natural Medicine, Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing 100050, ChinaPurified from the roots of the plant Sinomenium acutum, sinomenine is traditionally used in China and Japan for treating rheumatism and arthritis. Previously, we have demonstrated that sinomenine possessed a broad analgesic spectrum in various chronic pain animal models and repeated administration of sinomenine did not generate tolerance. In this review article, we discussed sinomenine’s analgesic mechanism with focus on its role on immune regulation and neuroimmune interaction. Sinomenine has distinct immunoregulative properties, in which glutamate, adenosine triphosphate, nitric oxide, and proinflammatory cytokines are thought to be involved. Sinomenine may alter the unbalanced neuroimmune interaction and inhibit neuroinflammation, oxidative stress, and central sensitization in chronic pain states. In conclusion, sinomenine has promising potential for chronic pain management in different clinical settings.http://dx.doi.org/10.1155/2020/1876862 |
| spellingShingle | Wei Jiang Weiming Fan Tianle Gao Tao Li Zhenming Yin Huihui Guo Lulu Wang Yanxing Han Jian-Dong Jiang Analgesic Mechanism of Sinomenine against Chronic Pain Pain Research and Management |
| title | Analgesic Mechanism of Sinomenine against Chronic Pain |
| title_full | Analgesic Mechanism of Sinomenine against Chronic Pain |
| title_fullStr | Analgesic Mechanism of Sinomenine against Chronic Pain |
| title_full_unstemmed | Analgesic Mechanism of Sinomenine against Chronic Pain |
| title_short | Analgesic Mechanism of Sinomenine against Chronic Pain |
| title_sort | analgesic mechanism of sinomenine against chronic pain |
| url | http://dx.doi.org/10.1155/2020/1876862 |
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