12,13-diHOME Promotes Inflammatory Macrophages and Epigenetically Modifies Their Capacity to Respond to Microbes and Allergens
Elevated infant fecal concentrations of the bacterial-derived lipid 12,13-dihydroxy-9Z-octadecenoic acid (12,13-diHOME) increase the risk for childhood atopy and asthma. However, the mechanisms by which this lipid contributes to disease development are largely unknown. We hypothesized that macrophag...
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Main Authors: | Din L. Lin, Kevin M. Magnaye, Cara E. Porsche, Sophia R. Levan, Elze Rackaityte, Mustafa Özçam, Susan V. Lynch |
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Format: | Article |
Language: | English |
Published: |
Wiley
2024-01-01
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Series: | Journal of Immunology Research |
Online Access: | http://dx.doi.org/10.1155/2024/2506586 |
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