SUGAR-seq reveals the transcriptome and N-linked glycosylation landscape of mononuclear phagocytes at single-cell resolution in a mouse model of autosomal dominant osteopetrosis type 2

SUGAR-seq reveals the transcriptome and N-linked glycosylation landscape of mononuclear phagocytes at single-cell resolution in a mouse model of autosomal dominant osteopetrosis type 2

Abstract Background Heterozygous mutation of CLCN7 (R286W) is commonly found in patients with benign autosomal dominant osteopetrosis. However, there is no evidence from animal models to confirm that it is a disease mutation. And the characteristics of the bone marrow cell (BMC) landscape in osteope...

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Bibliographic Details
Main Authors: Yu Sha, Lingyu Huang, Lei Zhang, Xianliang Hou, Chune Mo, Cuiping Pan, Gengshuo Chen, Sha Luo, Minglin Ou
Format: Article
Language:English
Published: BMC 2025-03-01
Series:BMC Biology
Subjects:
Osteopetrosis
Single-cell resolution
Mononuclear phagocytes
Glycoproteome
Online Access:https://doi.org/10.1186/s12915-025-02193-z
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https://doi.org/10.1186/s12915-025-02193-z

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