The structural and functional brain alternations in tobacco use disorder: a systematic review and meta-analysis
BackgroundWhile numerous previous studies have indicated that nicotine intake results in gray matter and functional brain abnormalities in tobacco use disorder (TUD), the majority of results could not be replicated or even reversed. Consequently, it is important to utilize relevant coordinate data f...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-04-01
|
| Series: | Frontiers in Psychiatry |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2025.1403604/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850189073071734784 |
|---|---|
| author | Longyao Ma Longyao Ma Qiuying Tao Qiuying Tao Jinghan Dang Jinghan Dang Jieping Sun Jieping Sun Xiaoyu Niu Xiaoyu Niu Mengzhe Zhang Mengzhe Zhang Yimeng Kang Yimeng Kang Weijian Wang Weijian Wang Jingliang Cheng Jingliang Cheng Yong Zhang Yong Zhang |
| author_facet | Longyao Ma Longyao Ma Qiuying Tao Qiuying Tao Jinghan Dang Jinghan Dang Jieping Sun Jieping Sun Xiaoyu Niu Xiaoyu Niu Mengzhe Zhang Mengzhe Zhang Yimeng Kang Yimeng Kang Weijian Wang Weijian Wang Jingliang Cheng Jingliang Cheng Yong Zhang Yong Zhang |
| author_sort | Longyao Ma |
| collection | DOAJ |
| description | BackgroundWhile numerous previous studies have indicated that nicotine intake results in gray matter and functional brain abnormalities in tobacco use disorder (TUD), the majority of results could not be replicated or even reversed. Consequently, it is important to utilize relevant coordinate data for a comprehensive meta-analysis to identify the shared patterns of structural, functional, and multimodal alternations in TUD.MethodThe present study conducted a systematic retrieval of studies published on PubMed, Web of Science, and Scopus from January 1, 2010, to December 12, 2023, to identify studies on voxel-based morphometry (VBM) and resting-state functional magnetic resonance imaging (rs-fMRI) for TUD. Then, two meta-analyses using the anisotropic seed-based d mapping method were used to detect brain comprehensive alterations in individuals with TUD. Furthermore, two meta-analyses were pooled for multimodal analysis to discover multimodal anomalies. Finally, subgroup analyses were performed to explore the sources of TUD heterogeneity from both methodological and age perspectives.ResultThis study encompassed a total of 25 VBM studies, including 1,249 individuals with TUD and 1,874 healthy controls (HCs), and 35 rs-fMRI studies, including 1,436 individuals with TUD and 1,550 HCs. For rs-fMRI analysis, individuals with TUD exhibited increased intrinsic function in the right cerebellum crus2, left superior frontal gyrus, left inferior parietal gyrus, and left supplementary motor area and decreased intrinsic function in the right gyrus rectus, right superior/middle frontal gyrus, and left inferior frontal gyrus. For VBM analysis, individuals with TUD showed decreased gray matter volume (GMV) in the left superior temporal gyrus, right superior frontal gyrus, right anterior cingulate/paracingulate gyrus, left superior frontal gyrus, and right anterior thalamic region and increased GMV in the right lingual gyrus.ConclusionThis meta-analysis illustrates structural and functional abnormalities of the default mode network, executive control network, and salience network in individuals with TUD. Multimodal analysis of the right lingual gyrus provided additional information, offering the potential for identifying more therapeutic targets for interventions against TUD. |
| format | Article |
| id | doaj-art-a7b8a2743c004f1f9b13e16eac70a7f7 |
| institution | OA Journals |
| issn | 1664-0640 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj-art-a7b8a2743c004f1f9b13e16eac70a7f72025-08-20T02:15:41ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402025-04-011610.3389/fpsyt.2025.14036041403604The structural and functional brain alternations in tobacco use disorder: a systematic review and meta-analysisLongyao Ma0Longyao Ma1Qiuying Tao2Qiuying Tao3Jinghan Dang4Jinghan Dang5Jieping Sun6Jieping Sun7Xiaoyu Niu8Xiaoyu Niu9Mengzhe Zhang10Mengzhe Zhang11Yimeng Kang12Yimeng Kang13Weijian Wang14Weijian Wang15Jingliang Cheng16Jingliang Cheng17Yong Zhang18Yong Zhang19Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaZhengzhou Key Laboratory of Brain Function and Cognitive Magnetic Resonance Imaging, Zhengzhou, ChinaDepartment of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaZhengzhou Key Laboratory of Brain Function and Cognitive Magnetic Resonance Imaging, Zhengzhou, ChinaDepartment of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaZhengzhou Key Laboratory of Brain Function and Cognitive Magnetic Resonance Imaging, Zhengzhou, ChinaDepartment of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaZhengzhou Key Laboratory of Brain Function and Cognitive Magnetic Resonance Imaging, Zhengzhou, ChinaDepartment of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaZhengzhou Key Laboratory of Brain Function and Cognitive Magnetic Resonance Imaging, Zhengzhou, ChinaDepartment of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaZhengzhou Key Laboratory of Brain Function and Cognitive Magnetic Resonance Imaging, Zhengzhou, ChinaDepartment of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaZhengzhou Key Laboratory of Brain Function and Cognitive Magnetic Resonance Imaging, Zhengzhou, ChinaDepartment of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaZhengzhou Key Laboratory of Brain Function and Cognitive Magnetic Resonance Imaging, Zhengzhou, ChinaDepartment of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaZhengzhou Key Laboratory of Brain Function and Cognitive Magnetic Resonance Imaging, Zhengzhou, ChinaDepartment of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaZhengzhou Key Laboratory of Brain Function and Cognitive Magnetic Resonance Imaging, Zhengzhou, ChinaBackgroundWhile numerous previous studies have indicated that nicotine intake results in gray matter and functional brain abnormalities in tobacco use disorder (TUD), the majority of results could not be replicated or even reversed. Consequently, it is important to utilize relevant coordinate data for a comprehensive meta-analysis to identify the shared patterns of structural, functional, and multimodal alternations in TUD.MethodThe present study conducted a systematic retrieval of studies published on PubMed, Web of Science, and Scopus from January 1, 2010, to December 12, 2023, to identify studies on voxel-based morphometry (VBM) and resting-state functional magnetic resonance imaging (rs-fMRI) for TUD. Then, two meta-analyses using the anisotropic seed-based d mapping method were used to detect brain comprehensive alterations in individuals with TUD. Furthermore, two meta-analyses were pooled for multimodal analysis to discover multimodal anomalies. Finally, subgroup analyses were performed to explore the sources of TUD heterogeneity from both methodological and age perspectives.ResultThis study encompassed a total of 25 VBM studies, including 1,249 individuals with TUD and 1,874 healthy controls (HCs), and 35 rs-fMRI studies, including 1,436 individuals with TUD and 1,550 HCs. For rs-fMRI analysis, individuals with TUD exhibited increased intrinsic function in the right cerebellum crus2, left superior frontal gyrus, left inferior parietal gyrus, and left supplementary motor area and decreased intrinsic function in the right gyrus rectus, right superior/middle frontal gyrus, and left inferior frontal gyrus. For VBM analysis, individuals with TUD showed decreased gray matter volume (GMV) in the left superior temporal gyrus, right superior frontal gyrus, right anterior cingulate/paracingulate gyrus, left superior frontal gyrus, and right anterior thalamic region and increased GMV in the right lingual gyrus.ConclusionThis meta-analysis illustrates structural and functional abnormalities of the default mode network, executive control network, and salience network in individuals with TUD. Multimodal analysis of the right lingual gyrus provided additional information, offering the potential for identifying more therapeutic targets for interventions against TUD.https://www.frontiersin.org/articles/10.3389/fpsyt.2025.1403604/fullmeta-analysistobacco use disordervoxel-based morphometryfunctional magnetic resonance imagingmultimodel neuroimaging |
| spellingShingle | Longyao Ma Longyao Ma Qiuying Tao Qiuying Tao Jinghan Dang Jinghan Dang Jieping Sun Jieping Sun Xiaoyu Niu Xiaoyu Niu Mengzhe Zhang Mengzhe Zhang Yimeng Kang Yimeng Kang Weijian Wang Weijian Wang Jingliang Cheng Jingliang Cheng Yong Zhang Yong Zhang The structural and functional brain alternations in tobacco use disorder: a systematic review and meta-analysis Frontiers in Psychiatry meta-analysis tobacco use disorder voxel-based morphometry functional magnetic resonance imaging multimodel neuroimaging |
| title | The structural and functional brain alternations in tobacco use disorder: a systematic review and meta-analysis |
| title_full | The structural and functional brain alternations in tobacco use disorder: a systematic review and meta-analysis |
| title_fullStr | The structural and functional brain alternations in tobacco use disorder: a systematic review and meta-analysis |
| title_full_unstemmed | The structural and functional brain alternations in tobacco use disorder: a systematic review and meta-analysis |
| title_short | The structural and functional brain alternations in tobacco use disorder: a systematic review and meta-analysis |
| title_sort | structural and functional brain alternations in tobacco use disorder a systematic review and meta analysis |
| topic | meta-analysis tobacco use disorder voxel-based morphometry functional magnetic resonance imaging multimodel neuroimaging |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2025.1403604/full |
| work_keys_str_mv | AT longyaoma thestructuralandfunctionalbrainalternationsintobaccousedisorderasystematicreviewandmetaanalysis AT longyaoma thestructuralandfunctionalbrainalternationsintobaccousedisorderasystematicreviewandmetaanalysis AT qiuyingtao thestructuralandfunctionalbrainalternationsintobaccousedisorderasystematicreviewandmetaanalysis AT qiuyingtao thestructuralandfunctionalbrainalternationsintobaccousedisorderasystematicreviewandmetaanalysis AT jinghandang thestructuralandfunctionalbrainalternationsintobaccousedisorderasystematicreviewandmetaanalysis AT jinghandang thestructuralandfunctionalbrainalternationsintobaccousedisorderasystematicreviewandmetaanalysis AT jiepingsun thestructuralandfunctionalbrainalternationsintobaccousedisorderasystematicreviewandmetaanalysis AT jiepingsun thestructuralandfunctionalbrainalternationsintobaccousedisorderasystematicreviewandmetaanalysis AT xiaoyuniu thestructuralandfunctionalbrainalternationsintobaccousedisorderasystematicreviewandmetaanalysis AT xiaoyuniu thestructuralandfunctionalbrainalternationsintobaccousedisorderasystematicreviewandmetaanalysis AT mengzhezhang thestructuralandfunctionalbrainalternationsintobaccousedisorderasystematicreviewandmetaanalysis AT mengzhezhang thestructuralandfunctionalbrainalternationsintobaccousedisorderasystematicreviewandmetaanalysis AT yimengkang thestructuralandfunctionalbrainalternationsintobaccousedisorderasystematicreviewandmetaanalysis AT yimengkang thestructuralandfunctionalbrainalternationsintobaccousedisorderasystematicreviewandmetaanalysis AT weijianwang thestructuralandfunctionalbrainalternationsintobaccousedisorderasystematicreviewandmetaanalysis AT weijianwang thestructuralandfunctionalbrainalternationsintobaccousedisorderasystematicreviewandmetaanalysis AT jingliangcheng thestructuralandfunctionalbrainalternationsintobaccousedisorderasystematicreviewandmetaanalysis AT jingliangcheng thestructuralandfunctionalbrainalternationsintobaccousedisorderasystematicreviewandmetaanalysis AT yongzhang thestructuralandfunctionalbrainalternationsintobaccousedisorderasystematicreviewandmetaanalysis AT yongzhang thestructuralandfunctionalbrainalternationsintobaccousedisorderasystematicreviewandmetaanalysis AT longyaoma structuralandfunctionalbrainalternationsintobaccousedisorderasystematicreviewandmetaanalysis AT longyaoma structuralandfunctionalbrainalternationsintobaccousedisorderasystematicreviewandmetaanalysis AT qiuyingtao structuralandfunctionalbrainalternationsintobaccousedisorderasystematicreviewandmetaanalysis AT qiuyingtao structuralandfunctionalbrainalternationsintobaccousedisorderasystematicreviewandmetaanalysis AT jinghandang structuralandfunctionalbrainalternationsintobaccousedisorderasystematicreviewandmetaanalysis AT jinghandang structuralandfunctionalbrainalternationsintobaccousedisorderasystematicreviewandmetaanalysis AT jiepingsun structuralandfunctionalbrainalternationsintobaccousedisorderasystematicreviewandmetaanalysis AT jiepingsun structuralandfunctionalbrainalternationsintobaccousedisorderasystematicreviewandmetaanalysis AT xiaoyuniu structuralandfunctionalbrainalternationsintobaccousedisorderasystematicreviewandmetaanalysis AT xiaoyuniu structuralandfunctionalbrainalternationsintobaccousedisorderasystematicreviewandmetaanalysis AT mengzhezhang structuralandfunctionalbrainalternationsintobaccousedisorderasystematicreviewandmetaanalysis AT mengzhezhang structuralandfunctionalbrainalternationsintobaccousedisorderasystematicreviewandmetaanalysis AT yimengkang structuralandfunctionalbrainalternationsintobaccousedisorderasystematicreviewandmetaanalysis AT yimengkang structuralandfunctionalbrainalternationsintobaccousedisorderasystematicreviewandmetaanalysis AT weijianwang structuralandfunctionalbrainalternationsintobaccousedisorderasystematicreviewandmetaanalysis AT weijianwang structuralandfunctionalbrainalternationsintobaccousedisorderasystematicreviewandmetaanalysis AT jingliangcheng structuralandfunctionalbrainalternationsintobaccousedisorderasystematicreviewandmetaanalysis AT jingliangcheng structuralandfunctionalbrainalternationsintobaccousedisorderasystematicreviewandmetaanalysis AT yongzhang structuralandfunctionalbrainalternationsintobaccousedisorderasystematicreviewandmetaanalysis AT yongzhang structuralandfunctionalbrainalternationsintobaccousedisorderasystematicreviewandmetaanalysis |