AzioInositols in the Treatment of Insulin-Mediated Diseases
A growing body of research is currently focused on the role of inositol isomers and in particular myo-inositol (MYO-INS) and D-chiroinositol (DCI) in the treatment of insulin resistance states. Both isomers have been shown to exert insulin-mimetic action and to lower postprandial glucose. Further, i...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2016/3058393 |
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| author | Giovanna Muscogiuri Stefano Palomba Antonio Simone Laganà Francesco Orio |
| author_facet | Giovanna Muscogiuri Stefano Palomba Antonio Simone Laganà Francesco Orio |
| author_sort | Giovanna Muscogiuri |
| collection | DOAJ |
| description | A growing body of research is currently focused on the role of inositol isomers and in particular myo-inositol (MYO-INS) and D-chiroinositol (DCI) in the treatment of insulin resistance states. Both isomers have been shown to exert insulin-mimetic action and to lower postprandial glucose. Further, insulin resistance-related diseases were associated to derangements in inositol metabolism. Thus, the aim of this review is to provide current evidence on the potential benefits of inositol isomers (MYO-INS and DCI) in the treatment of disease associated to insulin resistance such as polycystic ovary syndrome (PCOS), gestational diabetes, and metabolic syndrome. Finally, molecular insights into inositol insulin-sensitizing effects will be covered focusing on the possible role of inositol glycans as insulin second messengers. |
| format | Article |
| id | doaj-art-a7aa5ce9772e475a97d79cfb1b50a188 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-a7aa5ce9772e475a97d79cfb1b50a1882025-02-03T06:06:21ZengWileyInternational Journal of Endocrinology1687-83371687-83452016-01-01201610.1155/2016/30583933058393AzioInositols in the Treatment of Insulin-Mediated DiseasesGiovanna Muscogiuri0Stefano Palomba1Antonio Simone Laganà2Francesco Orio3IOS and Coleman Medicina Futura Medical Center, Centro Direzionale, 80143 Naples, ItalyDepartment of Obstetrics and Gynecology, Arcispedale Santa Maria Nuova-IRCCS, 42123 Reggio Emilia, ItalyUnit of Gynecology and Obstetrics, Department of Human Pathology in Adulthood and Childhood “G. Barresi”, University of Messina, 98125 Messina, ItalyEndocrinology, Department of Sports Science and Wellness, “Parthenope” University of Naples, 80133 Naples, ItalyA growing body of research is currently focused on the role of inositol isomers and in particular myo-inositol (MYO-INS) and D-chiroinositol (DCI) in the treatment of insulin resistance states. Both isomers have been shown to exert insulin-mimetic action and to lower postprandial glucose. Further, insulin resistance-related diseases were associated to derangements in inositol metabolism. Thus, the aim of this review is to provide current evidence on the potential benefits of inositol isomers (MYO-INS and DCI) in the treatment of disease associated to insulin resistance such as polycystic ovary syndrome (PCOS), gestational diabetes, and metabolic syndrome. Finally, molecular insights into inositol insulin-sensitizing effects will be covered focusing on the possible role of inositol glycans as insulin second messengers.http://dx.doi.org/10.1155/2016/3058393 |
| spellingShingle | Giovanna Muscogiuri Stefano Palomba Antonio Simone Laganà Francesco Orio AzioInositols in the Treatment of Insulin-Mediated Diseases International Journal of Endocrinology |
| title | AzioInositols in the Treatment of Insulin-Mediated Diseases |
| title_full | AzioInositols in the Treatment of Insulin-Mediated Diseases |
| title_fullStr | AzioInositols in the Treatment of Insulin-Mediated Diseases |
| title_full_unstemmed | AzioInositols in the Treatment of Insulin-Mediated Diseases |
| title_short | AzioInositols in the Treatment of Insulin-Mediated Diseases |
| title_sort | azioinositols in the treatment of insulin mediated diseases |
| url | http://dx.doi.org/10.1155/2016/3058393 |
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