Distinct roles for FOXP3 and FOXP3 CD4 T cells in regulating cellular immunity to uncomplicated and severe Plasmodium falciparum malaria.

Distinct roles for FOXP3 and FOXP3 CD4 T cells in regulating cellular immunity to uncomplicated and severe Plasmodium falciparum malaria.

Failure to establish an appropriate balance between pro- and anti-inflammatory immune responses is believed to contribute to pathogenesis of severe malaria. To determine whether this balance is maintained by classical regulatory T cells (CD4(+) FOXP3(+) CD127(-/low); Tregs) we compared cellular resp...

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Main Authors: Michael Walther, David Jeffries, Olivia C Finney, Madi Njie, Augustine Ebonyi, Susanne Deininger, Emma Lawrence, Alfred Ngwa-Amambua, Shamanthi Jayasooriya, Ian H Cheeseman, Natalia Gomez-Escobar, Joseph Okebe, David J Conway, Eleanor M Riley
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-04-01
Series:PLoS Pathogens
Online Access:https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1000364&type=printable
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https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1000364&type=printable

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