Cardiac Troponin T and Illness Severity in the Very-Low-Birth-Weight Infant
Introduction. Respiratory distress are very common in Very-low-birth-weight (VLBW) infants and Myocardial injury may play a role in the disease outcome. Cardiac troponin T (cTnT) is the most useful marker of injury in adult population, but has not been extensively studied in this population. Aim. T...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | International Journal of Pediatrics |
| Online Access: | http://dx.doi.org/10.1155/2012/479242 |
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| author | Danielle N. Lopes José M. Moraes Ramos Maria Elizabeth Lopes Moreira Jofre A. Cabral Manoel de Carvalho José Maria de Andrade Lopes |
| author_facet | Danielle N. Lopes José M. Moraes Ramos Maria Elizabeth Lopes Moreira Jofre A. Cabral Manoel de Carvalho José Maria de Andrade Lopes |
| author_sort | Danielle N. Lopes |
| collection | DOAJ |
| description | Introduction. Respiratory distress are very common in Very-low-birth-weight (VLBW) infants and Myocardial injury may play a role in the disease outcome. Cardiac troponin T (cTnT) is the most useful marker of injury in adult population, but has not been extensively studied in this population. Aim. To study the role of cTnT in VLBW infants and its association with clinical outcomes. Methods. All VLBW infants admitted to our NICU were included in the study. Echocardiography and blood samples for cTnT determination were collected at 24 and 48 hours of life, and values >0.1 ng/mL were considered CTnT-positive values. Results. A total of 116 neonates had their blood samples collected. The median cTnT concentration within 24 hours was 0.191 (0.1–0.79) ng/mL and within 48 hours was 0.293 (0.1–1.0) ng/mL. A logistic regression analysis showed that PDA, low GA, and use of dopamine were independently associated with positive cTnT and abnormal Dopplerfluxometry and diuretics use had protective effects and was independently associated with troponin values. Conclusion. We observed a high prevalence of positivecTnT values in VLBW infants associated with illness severity. Our findings suggest that cTnT may be a useful and early marker of myocardial injury in VLBW infants. |
| format | Article |
| id | doaj-art-a76b3ababfa14a0e8e58ed7f344464a8 |
| institution | Kabale University |
| issn | 1687-9740 1687-9759 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Pediatrics |
| spelling | doaj-art-a76b3ababfa14a0e8e58ed7f344464a82025-02-03T05:45:30ZengWileyInternational Journal of Pediatrics1687-97401687-97592012-01-01201210.1155/2012/479242479242Cardiac Troponin T and Illness Severity in the Very-Low-Birth-Weight InfantDanielle N. Lopes0José M. Moraes Ramos1Maria Elizabeth Lopes Moreira2Jofre A. Cabral3Manoel de Carvalho4José Maria de Andrade Lopes5Neonatal Intensive Care Unit, Clínica Perinatal Laranjeiras, 22240-002 Rio de Janeiro, BrazilDepartment of Neonatology, Instituto Fernandes Figueira, Oswaldo Cruz Foundation, 22250-020 Rio de Janeiro, BrazilDepartment of Neonatology, Instituto Fernandes Figueira, Oswaldo Cruz Foundation, 22250-020 Rio de Janeiro, BrazilNeonatal Intensive Care Unit, Clínica Perinatal Laranjeiras, 22240-002 Rio de Janeiro, BrazilNeonatal Intensive Care Unit, Clínica Perinatal Laranjeiras, 22240-002 Rio de Janeiro, BrazilNeonatal Intensive Care Unit, Clínica Perinatal Laranjeiras, 22240-002 Rio de Janeiro, BrazilIntroduction. Respiratory distress are very common in Very-low-birth-weight (VLBW) infants and Myocardial injury may play a role in the disease outcome. Cardiac troponin T (cTnT) is the most useful marker of injury in adult population, but has not been extensively studied in this population. Aim. To study the role of cTnT in VLBW infants and its association with clinical outcomes. Methods. All VLBW infants admitted to our NICU were included in the study. Echocardiography and blood samples for cTnT determination were collected at 24 and 48 hours of life, and values >0.1 ng/mL were considered CTnT-positive values. Results. A total of 116 neonates had their blood samples collected. The median cTnT concentration within 24 hours was 0.191 (0.1–0.79) ng/mL and within 48 hours was 0.293 (0.1–1.0) ng/mL. A logistic regression analysis showed that PDA, low GA, and use of dopamine were independently associated with positive cTnT and abnormal Dopplerfluxometry and diuretics use had protective effects and was independently associated with troponin values. Conclusion. We observed a high prevalence of positivecTnT values in VLBW infants associated with illness severity. Our findings suggest that cTnT may be a useful and early marker of myocardial injury in VLBW infants.http://dx.doi.org/10.1155/2012/479242 |
| spellingShingle | Danielle N. Lopes José M. Moraes Ramos Maria Elizabeth Lopes Moreira Jofre A. Cabral Manoel de Carvalho José Maria de Andrade Lopes Cardiac Troponin T and Illness Severity in the Very-Low-Birth-Weight Infant International Journal of Pediatrics |
| title | Cardiac Troponin T and Illness Severity in the Very-Low-Birth-Weight Infant |
| title_full | Cardiac Troponin T and Illness Severity in the Very-Low-Birth-Weight Infant |
| title_fullStr | Cardiac Troponin T and Illness Severity in the Very-Low-Birth-Weight Infant |
| title_full_unstemmed | Cardiac Troponin T and Illness Severity in the Very-Low-Birth-Weight Infant |
| title_short | Cardiac Troponin T and Illness Severity in the Very-Low-Birth-Weight Infant |
| title_sort | cardiac troponin t and illness severity in the very low birth weight infant |
| url | http://dx.doi.org/10.1155/2012/479242 |
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