Synthesis and Antimicrobial Activity of Quinazolinone Conjugated Peptides
Antimicrobial compounds were synthesized by coupling 4-(4-oxo-3,4-dihydroquinazolin-2-yl) butanoic acid with VP, GVP, VGVP and GVGVP peptides. Antimicrobial activities of the synthesized compounds were performed against various bacterial strains by disc diffusion method. The structure activity relat...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | E-Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2010/979675 |
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| author | G. P. Suresha K. C. Prakasha Wethroe Kapfo D. Channe Gowda |
| author_facet | G. P. Suresha K. C. Prakasha Wethroe Kapfo D. Channe Gowda |
| author_sort | G. P. Suresha |
| collection | DOAJ |
| description | Antimicrobial compounds were synthesized by coupling 4-(4-oxo-3,4-dihydroquinazolin-2-yl) butanoic acid with VP, GVP, VGVP and GVGVP peptides. Antimicrobial activities of the synthesized compounds were performed against various bacterial strains by disc diffusion method. The structure activity relationship was evaluated with respect to hydrophobicity, polarity, chain length of peptides and alkyl chain length of quinazolinone. Correlations of analogs with respect to their antimicrobial activity in comparison with conventional drugs and probable mechanism for the activity were discussed. |
| format | Article |
| id | doaj-art-a76404d926f04d5aa8c8544d2bd5b688 |
| institution | Kabale University |
| issn | 0973-4945 2090-9810 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | E-Journal of Chemistry |
| spelling | doaj-art-a76404d926f04d5aa8c8544d2bd5b6882025-02-03T05:45:30ZengWileyE-Journal of Chemistry0973-49452090-98102010-01-017244945610.1155/2010/979675Synthesis and Antimicrobial Activity of Quinazolinone Conjugated PeptidesG. P. Suresha0K. C. Prakasha1Wethroe Kapfo2D. Channe Gowda3Department of Chemistry, Manasagangotri, University of Mysore, Mysore-570006, IndiaDepartment of Chemistry, Manasagangotri, University of Mysore, Mysore-570006, IndiaDepartment of Chemistry, Manasagangotri, University of Mysore, Mysore-570006, IndiaDepartment of Chemistry, Manasagangotri, University of Mysore, Mysore-570006, IndiaAntimicrobial compounds were synthesized by coupling 4-(4-oxo-3,4-dihydroquinazolin-2-yl) butanoic acid with VP, GVP, VGVP and GVGVP peptides. Antimicrobial activities of the synthesized compounds were performed against various bacterial strains by disc diffusion method. The structure activity relationship was evaluated with respect to hydrophobicity, polarity, chain length of peptides and alkyl chain length of quinazolinone. Correlations of analogs with respect to their antimicrobial activity in comparison with conventional drugs and probable mechanism for the activity were discussed.http://dx.doi.org/10.1155/2010/979675 |
| spellingShingle | G. P. Suresha K. C. Prakasha Wethroe Kapfo D. Channe Gowda Synthesis and Antimicrobial Activity of Quinazolinone Conjugated Peptides E-Journal of Chemistry |
| title | Synthesis and Antimicrobial Activity of Quinazolinone Conjugated Peptides |
| title_full | Synthesis and Antimicrobial Activity of Quinazolinone Conjugated Peptides |
| title_fullStr | Synthesis and Antimicrobial Activity of Quinazolinone Conjugated Peptides |
| title_full_unstemmed | Synthesis and Antimicrobial Activity of Quinazolinone Conjugated Peptides |
| title_short | Synthesis and Antimicrobial Activity of Quinazolinone Conjugated Peptides |
| title_sort | synthesis and antimicrobial activity of quinazolinone conjugated peptides |
| url | http://dx.doi.org/10.1155/2010/979675 |
| work_keys_str_mv | AT gpsuresha synthesisandantimicrobialactivityofquinazolinoneconjugatedpeptides AT kcprakasha synthesisandantimicrobialactivityofquinazolinoneconjugatedpeptides AT wethroekapfo synthesisandantimicrobialactivityofquinazolinoneconjugatedpeptides AT dchannegowda synthesisandantimicrobialactivityofquinazolinoneconjugatedpeptides |