Adaptation to Arginine Deprivation Leads to a More Aggressive, Therapy-Resistant Phenotype in HNSCC Cells

Adaptation to Arginine Deprivation Leads to a More Aggressive, Therapy-Resistant Phenotype in HNSCC Cells

<i>Purpose:</i> The development of acquired resistance to arginine deprivation therapy (ADT) is a major barrier to its efficacy. This study aimed to elucidate the possible mechanisms underlying the resistance to ADT. <i>Methods:</i> We applied repeated ADT and established a s...

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Bibliographic Details
Main Authors: Oleg Chen, Olena Vovk, Nikita Polishchuk, Oksana Mayevska, Galyna Shuvayeva, Melike Demir, Vasyl Lukiyanchuk, Leoni A. Kunz-Schughart, Anna Dubrovska, Oleh Stasyk
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Biomolecules
Subjects:
arginine deprivation therapy
recombinant human arginase type 1
head and neck squamous cell carcinoma
acquired drug resistance
epithelial–mesenchymal transition
DNA repair
Online Access:https://www.mdpi.com/2218-273X/15/6/900
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