Inhaled sedation versus propofol in respiratory failure in the ICU (INSPiRE-ICU2): study protocol for a multicenter randomized controlled trial

Inhaled sedation versus propofol in respiratory failure in the ICU (INSPiRE-ICU2): study protocol for a multicenter randomized controlled trial

Abstract Background Patients undergoing invasive mechanical ventilation often require pharmacologic sedation to facilitate tolerance of this life-sustaining intervention, but sedatives currently used in routine care have substantial limitations. Isoflurane is an inhaled volatile anesthetic with phar...

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Main Authors: Brian O’Gara, Alexis L. Serra, Joshua A. Englert, Alisha Sachdev, Robert L. Owens, Steven Y. Chang, Pauline K. Park, Daniel Talmor, Ida Sverud, Peter Sackey, Jeremy R. Beitler
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Trials
Subjects:
Inhalation anesthetic
Isoflurane
Propofol
Moderate sedation
Deep sedation
Respiratory failure
Online Access:https://doi.org/10.1186/s13063-025-08791-0
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https://doi.org/10.1186/s13063-025-08791-0

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