NRF2 modulates WNT signaling pathway to enhance photodynamic therapy resistance in oral leukoplakia

NRF2 modulates WNT signaling pathway to enhance photodynamic therapy resistance in oral leukoplakia

Abstract Oral leukoplakia (OLK) is a common potentially malignant oral disorder with high risk of malignant transformation. While photodynamic therapy (PDT) offers a minimally invasive treatment for OLK, some patients show resistance to PDT and the mechanisms remain unclear. This study aims to ident...

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Bibliographic Details
Main Authors: Tiantian Xu, Liang Zhong, Qianxi Liu, Fei Wang, Wenjing Kuang, Jiaqi Liang, Dan Yang, Xikun Zhou, Hongxia Dan, Hang Zhao, Taiwen Li, Xin Zeng, Jing Li, Qianming Chen
Format: Article
Language:English
Published: Springer Nature 2025-06-01
Series:EMBO Molecular Medicine
Subjects:
Oral Leukoplakia
Photodynamic Therapy
Resistance
NRF2
WNT
Online Access:https://doi.org/10.1038/s44321-025-00256-w
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https://doi.org/10.1038/s44321-025-00256-w

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