Macrophage Migration Inhibitory Factor in Fetoplacental Tissues from Preeclamptic Pregnancies with or without Fetal Growth Restriction
The proinflammatory cytokine MIF (macrophage migration inhibitory factor) is involved in physiological and pathological processes in pregnancy. MIF maternal serum levels are increased in preeclampsia (PE). We hypothesize that pregnancy tissues are the source of MIF overexpression in PE. MIF protein...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
|
| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2012/639342 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832565665194573824 |
|---|---|
| author | Simona Cardaropoli Luana Paulesu Roberta Romagnoli Francesca Ietta Daniela Marzioni Mario Castellucci Alessandro Rolfo Elena Vasario Ettore Piccoli Tullia Todros |
| author_facet | Simona Cardaropoli Luana Paulesu Roberta Romagnoli Francesca Ietta Daniela Marzioni Mario Castellucci Alessandro Rolfo Elena Vasario Ettore Piccoli Tullia Todros |
| author_sort | Simona Cardaropoli |
| collection | DOAJ |
| description | The proinflammatory cytokine MIF (macrophage migration inhibitory factor) is involved in physiological and pathological processes in pregnancy. MIF maternal serum levels are increased in preeclampsia (PE). We hypothesize that pregnancy tissues are the source of MIF overexpression in PE.
MIF protein was studied in maternal sera, placental tissues, fetal membranes, and umbilical cord of 8 control and 20 PE pregnancies: 10 with normal fetal growth (PE-AGA) and 10 with fetal growth restriction (PE-FGR).
MIF levels were significantly higher in PE-AGA membranes than in controls and PE-FGR. In PE-FGR, MIF cord concentrations were higher than in PE-AGA while MIF placental levels were lower than in controls. MIF maternal serum levels were higher in PE, compared to controls, and the difference was mainly due to PE-FGR samples.
These data support MIF involvement in PE pathogenesis and suggest that different pregnancy tissues contribute to MIF production in PE with and without fetoplacental compromise. |
| format | Article |
| id | doaj-art-a70dbc2de23943b5b32a1c460d835a8b |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-a70dbc2de23943b5b32a1c460d835a8b2025-02-03T01:07:03ZengWileyClinical and Developmental Immunology1740-25221740-25302012-01-01201210.1155/2012/639342639342Macrophage Migration Inhibitory Factor in Fetoplacental Tissues from Preeclamptic Pregnancies with or without Fetal Growth RestrictionSimona Cardaropoli0Luana Paulesu1Roberta Romagnoli2Francesca Ietta3Daniela Marzioni4Mario Castellucci5Alessandro Rolfo6Elena Vasario7Ettore Piccoli8Tullia Todros9Department of Obstetrics and Gynecology, University of Turin, Sant’Anna Hospital, Via Ventimiglia 3, 10126 Torino, ItalyDepartment of Physiology, University of Siena, Via Aldo Moro 4 53100 Siena, ItalyDepartment of Physiology, University of Siena, Via Aldo Moro 4 53100 Siena, ItalyDepartment of Physiology, University of Siena, Via Aldo Moro 4 53100 Siena, ItalyDepartment of Molecular Pathology and Innovative Therapies, Marche Polytechnic University, Via Tronto 10/a 60020 Ancona, ItalyDepartment of Molecular Pathology and Innovative Therapies, Marche Polytechnic University, Via Tronto 10/a 60020 Ancona, ItalyDepartment of Obstetrics and Gynecology, University of Turin, Sant’Anna Hospital, Via Ventimiglia 3, 10126 Torino, ItalyDepartment of Obstetrics and Gynecology, University of Turin, Sant’Anna Hospital, Via Ventimiglia 3, 10126 Torino, ItalyDepartment of Obstetrics and Gynecology, University of Turin, Sant’Anna Hospital, Via Ventimiglia 3, 10126 Torino, ItalyDepartment of Obstetrics and Gynecology, University of Turin, Sant’Anna Hospital, Via Ventimiglia 3, 10126 Torino, ItalyThe proinflammatory cytokine MIF (macrophage migration inhibitory factor) is involved in physiological and pathological processes in pregnancy. MIF maternal serum levels are increased in preeclampsia (PE). We hypothesize that pregnancy tissues are the source of MIF overexpression in PE. MIF protein was studied in maternal sera, placental tissues, fetal membranes, and umbilical cord of 8 control and 20 PE pregnancies: 10 with normal fetal growth (PE-AGA) and 10 with fetal growth restriction (PE-FGR). MIF levels were significantly higher in PE-AGA membranes than in controls and PE-FGR. In PE-FGR, MIF cord concentrations were higher than in PE-AGA while MIF placental levels were lower than in controls. MIF maternal serum levels were higher in PE, compared to controls, and the difference was mainly due to PE-FGR samples. These data support MIF involvement in PE pathogenesis and suggest that different pregnancy tissues contribute to MIF production in PE with and without fetoplacental compromise.http://dx.doi.org/10.1155/2012/639342 |
| spellingShingle | Simona Cardaropoli Luana Paulesu Roberta Romagnoli Francesca Ietta Daniela Marzioni Mario Castellucci Alessandro Rolfo Elena Vasario Ettore Piccoli Tullia Todros Macrophage Migration Inhibitory Factor in Fetoplacental Tissues from Preeclamptic Pregnancies with or without Fetal Growth Restriction Clinical and Developmental Immunology |
| title | Macrophage Migration Inhibitory Factor in Fetoplacental Tissues from Preeclamptic Pregnancies with or without Fetal Growth Restriction |
| title_full | Macrophage Migration Inhibitory Factor in Fetoplacental Tissues from Preeclamptic Pregnancies with or without Fetal Growth Restriction |
| title_fullStr | Macrophage Migration Inhibitory Factor in Fetoplacental Tissues from Preeclamptic Pregnancies with or without Fetal Growth Restriction |
| title_full_unstemmed | Macrophage Migration Inhibitory Factor in Fetoplacental Tissues from Preeclamptic Pregnancies with or without Fetal Growth Restriction |
| title_short | Macrophage Migration Inhibitory Factor in Fetoplacental Tissues from Preeclamptic Pregnancies with or without Fetal Growth Restriction |
| title_sort | macrophage migration inhibitory factor in fetoplacental tissues from preeclamptic pregnancies with or without fetal growth restriction |
| url | http://dx.doi.org/10.1155/2012/639342 |
| work_keys_str_mv | AT simonacardaropoli macrophagemigrationinhibitoryfactorinfetoplacentaltissuesfrompreeclampticpregnancieswithorwithoutfetalgrowthrestriction AT luanapaulesu macrophagemigrationinhibitoryfactorinfetoplacentaltissuesfrompreeclampticpregnancieswithorwithoutfetalgrowthrestriction AT robertaromagnoli macrophagemigrationinhibitoryfactorinfetoplacentaltissuesfrompreeclampticpregnancieswithorwithoutfetalgrowthrestriction AT francescaietta macrophagemigrationinhibitoryfactorinfetoplacentaltissuesfrompreeclampticpregnancieswithorwithoutfetalgrowthrestriction AT danielamarzioni macrophagemigrationinhibitoryfactorinfetoplacentaltissuesfrompreeclampticpregnancieswithorwithoutfetalgrowthrestriction AT mariocastellucci macrophagemigrationinhibitoryfactorinfetoplacentaltissuesfrompreeclampticpregnancieswithorwithoutfetalgrowthrestriction AT alessandrorolfo macrophagemigrationinhibitoryfactorinfetoplacentaltissuesfrompreeclampticpregnancieswithorwithoutfetalgrowthrestriction AT elenavasario macrophagemigrationinhibitoryfactorinfetoplacentaltissuesfrompreeclampticpregnancieswithorwithoutfetalgrowthrestriction AT ettorepiccoli macrophagemigrationinhibitoryfactorinfetoplacentaltissuesfrompreeclampticpregnancieswithorwithoutfetalgrowthrestriction AT tulliatodros macrophagemigrationinhibitoryfactorinfetoplacentaltissuesfrompreeclampticpregnancieswithorwithoutfetalgrowthrestriction |