PCSK9: A Potential Therapeutic Target for Sepsis
Sepsis is a life-threatening organ dysfunction syndrome caused by a dysregulated host response to infection. Proprotein convertase subtilisin/kexin type 9 (PCSK9) is often upregulated in the presence of sepsis and infectious diseases. In sepsis, PCSK9 degraded the low-density lipoprotein cholesterol...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2020/2687692 |
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| _version_ | 1832547797959704576 |
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| author | Yuan Yuan Wei Wu Shanshan Sun Yi Zhang Zhi Chen |
| author_facet | Yuan Yuan Wei Wu Shanshan Sun Yi Zhang Zhi Chen |
| author_sort | Yuan Yuan |
| collection | DOAJ |
| description | Sepsis is a life-threatening organ dysfunction syndrome caused by a dysregulated host response to infection. Proprotein convertase subtilisin/kexin type 9 (PCSK9) is often upregulated in the presence of sepsis and infectious diseases. In sepsis, PCSK9 degraded the low-density lipoprotein cholesterol (LDL) receptors (LDL-R) of the hepatocytes and the very low-density lipoprotein cholesterol receptors (VLDL-R) of the adipocytes, which then subsequently reduced pathogenic lipid uptake and clearance/sequestration. Moreover, it might improve cholesterol accumulation and augment toll-like receptor function in macrophages, which supported inflammatory responses. Accordingly, PCSK9 might show detrimental effects on immune host response and survival in sepsis. However, the exact roles of PCSK9 in the pathogenesis of sepsis are still not well defined. In this review, we summarized the literatures focusing on the roles of PCSK9 in sepsis. Our review provided an additional insight in the role of PCSK9 in sepsis, which might serve as a potential target for the treatment of sepsis. |
| format | Article |
| id | doaj-art-a6f5eaec76d14aad9dbcba09f825be8b |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-a6f5eaec76d14aad9dbcba09f825be8b2025-02-03T06:43:30ZengWileyJournal of Immunology Research2314-88612314-71562020-01-01202010.1155/2020/26876922687692PCSK9: A Potential Therapeutic Target for SepsisYuan Yuan0Wei Wu1Shanshan Sun2Yi Zhang3Zhi Chen4Department of Neurology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, ChinaState Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, ChinaState Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, ChinaDepartment of Laboratory Medicine, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, ChinaState Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, ChinaSepsis is a life-threatening organ dysfunction syndrome caused by a dysregulated host response to infection. Proprotein convertase subtilisin/kexin type 9 (PCSK9) is often upregulated in the presence of sepsis and infectious diseases. In sepsis, PCSK9 degraded the low-density lipoprotein cholesterol (LDL) receptors (LDL-R) of the hepatocytes and the very low-density lipoprotein cholesterol receptors (VLDL-R) of the adipocytes, which then subsequently reduced pathogenic lipid uptake and clearance/sequestration. Moreover, it might improve cholesterol accumulation and augment toll-like receptor function in macrophages, which supported inflammatory responses. Accordingly, PCSK9 might show detrimental effects on immune host response and survival in sepsis. However, the exact roles of PCSK9 in the pathogenesis of sepsis are still not well defined. In this review, we summarized the literatures focusing on the roles of PCSK9 in sepsis. Our review provided an additional insight in the role of PCSK9 in sepsis, which might serve as a potential target for the treatment of sepsis.http://dx.doi.org/10.1155/2020/2687692 |
| spellingShingle | Yuan Yuan Wei Wu Shanshan Sun Yi Zhang Zhi Chen PCSK9: A Potential Therapeutic Target for Sepsis Journal of Immunology Research |
| title | PCSK9: A Potential Therapeutic Target for Sepsis |
| title_full | PCSK9: A Potential Therapeutic Target for Sepsis |
| title_fullStr | PCSK9: A Potential Therapeutic Target for Sepsis |
| title_full_unstemmed | PCSK9: A Potential Therapeutic Target for Sepsis |
| title_short | PCSK9: A Potential Therapeutic Target for Sepsis |
| title_sort | pcsk9 a potential therapeutic target for sepsis |
| url | http://dx.doi.org/10.1155/2020/2687692 |
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