Reciprocal regulation between DNMT3A/3B and microRNAs miRs-299-3p/-30e is a causal factor for the downregulation of microRNAs targeting androgen receptor in prostate cancer

Reciprocal regulation between DNMT3A/3B and microRNAs miRs-299-3p/-30e is a causal factor for the downregulation of microRNAs targeting androgen receptor in prostate cancer

Background: Promoter hypermethylation is one of the events that downregulate microRNAs (miRNA), resulting in the differential expression of genes implicated in the progression of cancer. We previously reported that microRNAs (miRNA)-299-3p and −30e target androgen receptor (AR) and are downregulated...

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Bibliographic Details
Main Authors: Kavya Ganapathy, Christian F. Harrs, Samuel Harris, Stephen J. Staklinski, Ayman Khatib, Jong Y. Park, Ratna Chakrabarti
Format: Article
Language:English
Published: Elsevier 2025-02-01
Series:Heliyon
Subjects:
MicroRNA
Promoter methylation
DNMT
Prostate cancer disparity
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844025003287
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