Ileal microbial microbiome and its secondary bile acids modulate susceptibility to nonalcoholic steatohepatitis in dairy goats

Ileal microbial microbiome and its secondary bile acids modulate susceptibility to nonalcoholic steatohepatitis in dairy goats

Abstract Background Liver damage from nonalcoholic steatohepatitis (NASH) presents a significant challenge to the health and productivity of ruminants. However, the regulatory mechanisms behind variations in NASH susceptibility remain unclear. The gut‒liver axis, particularly the enterohepatic circu...

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Main Authors: Yue Wang, Xiaodong Chen, Sharon A. Huws, Guanghao Xu, Jing Li, Jianrong Ren, Jingyi Xu, Le Luo Guan, Junhu Yao, Shengru Wu
Format: Article
Language:English
Published: BMC 2024-11-01
Series:Microbiome
Subjects:
Nonalcoholic steatohepatitis susceptibility
Intrahepatic TH17 cells and Treg cells
Ileal microbiome
Secondary bile acids
Dairy goats
Online Access:https://doi.org/10.1186/s40168-024-01964-0
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https://doi.org/10.1186/s40168-024-01964-0

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