Hypoxia-induced genome-wide DNA demethylation by DNMT3A and EMT of cancer cells

Hypoxia-induced genome-wide DNA demethylation by DNMT3A and EMT of cancer cells

Abstract Background Despite the comprehensive advancement in the field of cancer therapeutics, there remains an urgent need to identify new pathophysiological mechanisms that can be targeted in isolation or in combination with existing therapeutic regimens. The epithelial-to-mesenchymal transitions...

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Main Authors: Biswanath Chatterjee, Pritha Majumder, Chun-Chang Chen, Jing-Ping Wang, Po-Hsuan Su, Hung-Cheng Lai, Ching-Chen Liu, Hsin-Nan Lin, Chen-Hsin A. Yu, Hanna S. Yuan, Che-Kun James Shen
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Cellular & Molecular Biology Letters
Subjects:
Hypoxia
EMT of cancer cells
Epigenetic regulation
DNA demethylation
DNMT3A
Histone modifications
Online Access:https://doi.org/10.1186/s11658-025-00775-x
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