Differences in the intrahepatic expression of immune checkpoint molecules on T cells and natural killer cells in chronic HBV patients

Differences in the intrahepatic expression of immune checkpoint molecules on T cells and natural killer cells in chronic HBV patients

BackgroundPatients with chronic hepatitis B virus (HBV) infection are characterized by impaired immune response that fails to eliminate HBV. Immune checkpoint molecules (ICMs) control the amplitude of the activation and function of immune cells, which makes them the key regulators of immune response...

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Main Authors: Lucile Dumolard, Marie-Noelle Hilleret, Charlotte Costentin, Marion Mercey-Ressejac, Nathalie Sturm, Theophile Gerster, Thomas Decaens, Evelyne Jouvin-Marche, Patrice N. Marche, Zuzana Macek Jilkova
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Immunology
Subjects:
HBV
PD-1
4-1BB
immune checkpoint molecules
liver
T cells
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1489770/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2024.1489770/full

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