Joint fluid multi-omics improves diagnostic confidence during evaluation of children with presumed septic arthritis

Joint fluid multi-omics improves diagnostic confidence during evaluation of children with presumed septic arthritis

Abstract Background An accurate diagnosis of septic versus reactive or autoimmune arthritis remains clinically challenging. A multi-omics strategy comprising metagenomic and proteomic technologies were undertaken for children diagnosed with presumed septic arthritis to advance clinical diagnoses and...

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Main Authors: Yolanda Peña-López, Naureen G. Tareen, Bo Zhang, Indu Raman, Carlos A. Arana, Chengsong Zhu, Yang Liu, Pratibha Selvakumar, Nicolai S. C. van Oers, Simrat Morris, Lora V. Hooper, Lawson A. B. Copley, Prithvi Raj
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Pediatric Rheumatology Online Journal
Subjects:
Autoimmune
Cytokine Infection
16S rRNA bacterial sequencing
Metagenomics
Next-generation sequencing (NGS)
Pediatric
Online Access:https://doi.org/10.1186/s12969-025-01060-z
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https://doi.org/10.1186/s12969-025-01060-z

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