Identification and replication of three novel myopia common susceptibility gene loci on chromosome 3q26 using linkage and linkage disequilibrium mapping.

Identification and replication of three novel myopia common susceptibility gene loci on chromosome 3q26 using linkage and linkage disequilibrium mapping.

Refractive error is a highly heritable quantitative trait responsible for considerable morbidity. Following an initial genome-wide linkage study using microsatellite markers, we confirmed evidence for linkage to chromosome 3q26 and then conducted fine-scale association mapping using high-resolution...

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Main Authors: Toby Andrew, Nikolas Maniatis, Francis Carbonaro, S H Melissa Liew, Winston Lau, Tim D Spector, Christopher J Hammond
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-10-01
Series:PLoS Genetics
Online Access:https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1000220&type=printable
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https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1000220&type=printable

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