TM4SF1 overexpression in tumor-associated endothelial cells promotes microvascular invasion in hepatocellular carcinoma

TM4SF1 overexpression in tumor-associated endothelial cells promotes microvascular invasion in hepatocellular carcinoma

BackgroundMicrovascular invasion (MVI) is linked to poor prognosis, early recurrence and post-surgical intrahepatic metastasis of hepatocellular carcinoma (HCC) but roles of tumor-associated endothelial cells (TECs) remain unclear. The aim of the current study was to investigate the role of TECs in...

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Bibliographic Details
Main Authors: Junwu Guo, Liangrui Chen, Binghua Dai, Chengjun Sui, Zhitao Dong, Keji Chen, Kecai Duan, Kunpeng Fang, Aijun Li, Kui Wang, Li Geng
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Frontiers in Oncology
Subjects:
hepatocellular carcinoma
ScRNA-seq
spatial transcriptomics
tumor-associated endothelial cells
TM4SF1
epithelial-mesenchymal transition
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2025.1526177/full
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https://www.frontiersin.org/articles/10.3389/fonc.2025.1526177/full

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