Behaviour of Human Erythrocyte Aggregation in Presence of Autologous Lipoproteins
The aim of this work was to evaluate in vitro the effect of autologous plasma lipoprotein subfractions on erythrocyte tendency to aggregate. Aliquots of human blood samples were enriched or not (control) with t...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
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| Series: | Biochemistry Research International |
| Online Access: | http://dx.doi.org/10.1155/2012/261736 |
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| Summary: | The aim of this work was to evaluate in vitro the effect
of autologous plasma lipoprotein subfractions on erythrocyte tendency
to aggregate. Aliquots of human blood samples were enriched or not
(control) with their own HDL-C, LDL-C, or VLDL-C fractions obtained
from the same batch by density gradient ultracentrifugation. Plasma
osmolality and erythrocyte aggregation index (EAI) were determined.
Blood aliquots enriched with LDL-C and HDL-C showed significant higher
EAI than untreated aliquots, whereas enrichment with VLDL-C does not
induce significant EAI changes. For the same range of lipoprotein
concentrations expressed as percentage of osmolality variation, the
EAI variation was positive and higher in presence of HDL-C than upon
enrichment with LDL-C (P<0.01). Particle size, up to LDL diameter values, seems to
reinforce erythrocyte tendency to aggregate at the same plasma
osmolality (particle number) range of values. |
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| ISSN: | 2090-2247 2090-2255 |