NETs activate the GAS6-AXL-NLRP3 axis in macrophages to drive morphine tolerance

NETs activate the GAS6-AXL-NLRP3 axis in macrophages to drive morphine tolerance

Abstract Background The development of morphine tolerance presents a major clinical challenge in the effective management of severe pain. This study aims to explore the mechanisms underlying morphine tolerance from a novel perspective, with the ultimate goal of uncovering new insights and identifyin...

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Bibliographic Details
Main Authors: Qingyan Tian, Haiyue Guo, Mengyao Zhang, Kunmao Jiang, Fan Hu, Yan Xu, Li Wan, Xiaokai Zhou, Yinbing Pan, Wentao Liu, Chun-Yi Jiang
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Cell Communication and Signaling
Subjects:
Morphine tolerance
NETs
GAS6
AXL
NLRP3
Online Access:https://doi.org/10.1186/s12964-025-02181-4
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