SpaNorm: spatially-aware normalization for spatial transcriptomics data

SpaNorm: spatially-aware normalization for spatial transcriptomics data

Abstract Normalization of spatial transcriptomics data is challenging due to spatial association between region-specific library size and biology. We develop SpaNorm, the first spatially-aware normalization method that concurrently models library size effects and the underlying biology, segregates t...

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Bibliographic Details
Main Authors: Agus Salim, Dharmesh D. Bhuva, Carissa Chen, Chin Wee Tan, Pengyi Yang, Melissa J. Davis, Jean Y. H. Yang
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Genome Biology
Online Access:https://doi.org/10.1186/s13059-025-03565-y
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