SpaNorm: spatially-aware normalization for spatial transcriptomics data
Abstract Normalization of spatial transcriptomics data is challenging due to spatial association between region-specific library size and biology. We develop SpaNorm, the first spatially-aware normalization method that concurrently models library size effects and the underlying biology, segregates t...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-04-01
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| Series: | Genome Biology |
| Online Access: | https://doi.org/10.1186/s13059-025-03565-y |
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