Seroprevalence against Rickettsia and Borrelia Species in Patients with Uveitis: A Prospective Survey
Vector-borne diseases such as Lyme borreliosis and rickettsioses have been associated with ocular inflammation. Our aim was to study patients with diagnosed uveitis to evaluate serological signs of infection or exposure to these tick-borne agents. Forty-eight patients were prospectively examined wit...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2017/9247465 |
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| author | Kim B. Madsen Katarina Wallménius Åke Fridman Carl Påhlson Kenneth Nilsson |
| author_facet | Kim B. Madsen Katarina Wallménius Åke Fridman Carl Påhlson Kenneth Nilsson |
| author_sort | Kim B. Madsen |
| collection | DOAJ |
| description | Vector-borne diseases such as Lyme borreliosis and rickettsioses have been associated with ocular inflammation. Our aim was to study patients with diagnosed uveitis to evaluate serological signs of infection or exposure to these tick-borne agents. Forty-eight patients were prospectively examined with serology together with medical records and a questionnaire concerning previous exposure, diseases, and treatments. Seven patients (14.6%) showed seroconversion to Rickettsia spp. between acute and convalescent phase sera, which provides support for a positive Rickettsia diagnosis according to guidelines. The specificity was confirmed by Western blot. Additional 28 patients had stationary titres of which eight (16.6%) had 1 : 256 or higher titre in the first serum, and another 13 patients were seronegative. No epidemiological risk factor or marker could be identified. For Borrelia, only three patients showed moderate IgG titres. A control group of 100 blood donors, 60 patients with rheumatic disease, and 56 patients seeking medical care were tested of which 2.0–7.1% showed low anti-Rickettsia titres and 3.0–8.3% anti-Borrelia titres. The findings are indicative for an association between infection or exposure to Rickettsia spp. and uveitis with a seropositivity among patients with recurrent uveitis in concordance with the spread of rickettsial exposure in a tick-exposed population. |
| format | Article |
| id | doaj-art-a60f1666ca054d04954f5c254ddf3a36 |
| institution | Kabale University |
| issn | 2090-004X 2090-0058 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-a60f1666ca054d04954f5c254ddf3a362025-02-03T01:12:22ZengWileyJournal of Ophthalmology2090-004X2090-00582017-01-01201710.1155/2017/92474659247465Seroprevalence against Rickettsia and Borrelia Species in Patients with Uveitis: A Prospective SurveyKim B. Madsen0Katarina Wallménius1Åke Fridman2Carl Påhlson3Kenneth Nilsson4Section of Opthalmology, Falu Hospital, Falun, SwedenDepartment of Medical Sciences, Section of Clinical Microbiology, Uppsala University, Uppsala, SwedenSection of Opthalmology, Falu Hospital, Falun, SwedenDepartment of Medical Sciences, Section of Clinical Microbiology, Uppsala University, Uppsala, SwedenDepartment of Medical Sciences, Section of Clinical Microbiology, Uppsala University, Uppsala, SwedenVector-borne diseases such as Lyme borreliosis and rickettsioses have been associated with ocular inflammation. Our aim was to study patients with diagnosed uveitis to evaluate serological signs of infection or exposure to these tick-borne agents. Forty-eight patients were prospectively examined with serology together with medical records and a questionnaire concerning previous exposure, diseases, and treatments. Seven patients (14.6%) showed seroconversion to Rickettsia spp. between acute and convalescent phase sera, which provides support for a positive Rickettsia diagnosis according to guidelines. The specificity was confirmed by Western blot. Additional 28 patients had stationary titres of which eight (16.6%) had 1 : 256 or higher titre in the first serum, and another 13 patients were seronegative. No epidemiological risk factor or marker could be identified. For Borrelia, only three patients showed moderate IgG titres. A control group of 100 blood donors, 60 patients with rheumatic disease, and 56 patients seeking medical care were tested of which 2.0–7.1% showed low anti-Rickettsia titres and 3.0–8.3% anti-Borrelia titres. The findings are indicative for an association between infection or exposure to Rickettsia spp. and uveitis with a seropositivity among patients with recurrent uveitis in concordance with the spread of rickettsial exposure in a tick-exposed population.http://dx.doi.org/10.1155/2017/9247465 |
| spellingShingle | Kim B. Madsen Katarina Wallménius Åke Fridman Carl Påhlson Kenneth Nilsson Seroprevalence against Rickettsia and Borrelia Species in Patients with Uveitis: A Prospective Survey Journal of Ophthalmology |
| title | Seroprevalence against Rickettsia and Borrelia Species in Patients with Uveitis: A Prospective Survey |
| title_full | Seroprevalence against Rickettsia and Borrelia Species in Patients with Uveitis: A Prospective Survey |
| title_fullStr | Seroprevalence against Rickettsia and Borrelia Species in Patients with Uveitis: A Prospective Survey |
| title_full_unstemmed | Seroprevalence against Rickettsia and Borrelia Species in Patients with Uveitis: A Prospective Survey |
| title_short | Seroprevalence against Rickettsia and Borrelia Species in Patients with Uveitis: A Prospective Survey |
| title_sort | seroprevalence against rickettsia and borrelia species in patients with uveitis a prospective survey |
| url | http://dx.doi.org/10.1155/2017/9247465 |
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