Predictors of Functional and Quality of Life Outcomes following Deep Brain Stimulation Surgery in Parkinson’s Disease Patients: Disease, Patient, and Surgical Factors
Objective. The primary objective was to evaluate predictors of quality of life (QOL) and functional outcomes following deep brain stimulation (DBS) in Parkinson’s disease (PD) patients. The secondary objective was to identify predictors of global improvement. Methods. PD patients who underwent DBS a...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Parkinson's Disease |
| Online Access: | http://dx.doi.org/10.1155/2017/5609163 |
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| author | Hesham Abboud Gencer Genc Nicolas R. Thompson Srivadee Oravivattanakul Faisal Alsallom Dennys Reyes Kathy Wilson Russell Cerejo Xin Xin Yu Darlene Floden Anwar Ahmed Michal Gostkowski Ayman Ezzeldin Hazem Marouf Ossama Y. Mansour Andre Machado Hubert H. Fernandez |
| author_facet | Hesham Abboud Gencer Genc Nicolas R. Thompson Srivadee Oravivattanakul Faisal Alsallom Dennys Reyes Kathy Wilson Russell Cerejo Xin Xin Yu Darlene Floden Anwar Ahmed Michal Gostkowski Ayman Ezzeldin Hazem Marouf Ossama Y. Mansour Andre Machado Hubert H. Fernandez |
| author_sort | Hesham Abboud |
| collection | DOAJ |
| description | Objective. The primary objective was to evaluate predictors of quality of life (QOL) and functional outcomes following deep brain stimulation (DBS) in Parkinson’s disease (PD) patients. The secondary objective was to identify predictors of global improvement. Methods. PD patients who underwent DBS at our Center from 2006 to 2011 were evaluated by chart review and email/phone survey. Postoperative UPDRS II and EQ-5D were analyzed using simple linear regression adjusting for preoperative score. For global outcomes, we utilized the Patient Global Impression of Change Scale (PGIS) and the Clinician Global Impression of Change Scale (CGIS). Results. There were 130 patients in the dataset. Preoperative and postoperative UPDRS II and EQ-5D were available for 45 patients, PGIS for 67 patients, and CGIS for 116 patients. Patients with falls/postural instability had 6-month functional scores and 1-year QOL scores that were significantly worse than patients without falls/postural instability. For every 1-point increase in preoperative UPDRS III and for every 1-unit increase in body mass index (BMI), the 6-month functional scores significantly worsened. Patients with tremors, without dyskinesia, and without gait-freezing were more likely to have “much” or “very much” improved CGIS. Conclusions. Presence of postural instability, high BMI, and worse baseline motor scores were the greatest predictors of poorer functional and QOL outcomes after DBS. |
| format | Article |
| id | doaj-art-a6076898d6b74c76ac60c2e2a04b1284 |
| institution | Kabale University |
| issn | 2090-8083 2042-0080 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Parkinson's Disease |
| spelling | doaj-art-a6076898d6b74c76ac60c2e2a04b12842025-02-03T06:10:58ZengWileyParkinson's Disease2090-80832042-00802017-01-01201710.1155/2017/56091635609163Predictors of Functional and Quality of Life Outcomes following Deep Brain Stimulation Surgery in Parkinson’s Disease Patients: Disease, Patient, and Surgical FactorsHesham Abboud0Gencer Genc1Nicolas R. Thompson2Srivadee Oravivattanakul3Faisal Alsallom4Dennys Reyes5Kathy Wilson6Russell Cerejo7Xin Xin Yu8Darlene Floden9Anwar Ahmed10Michal Gostkowski11Ayman Ezzeldin12Hazem Marouf13Ossama Y. Mansour14Andre Machado15Hubert H. Fernandez16Center for Neurological Restoration, Cleveland Clinic, 9500 Euclid Avenue, Mail Code U2, Cleveland, OH 44195, USACenter for Neurological Restoration, Cleveland Clinic, 9500 Euclid Avenue, Mail Code U2, Cleveland, OH 44195, USADepartment of Quantitative Health Sciences, Cleveland Clinic, 9500 Euclid Avenue, Mail Code JJN3-01, Cleveland, OH 44195, USACenter for Neurological Restoration, Cleveland Clinic, 9500 Euclid Avenue, Mail Code U2, Cleveland, OH 44195, USACase Western Reserve University, University Hospitals of Cleveland, 11100 Euclid Avenue, Cleveland, OH 44106, USADepartment of Neurology, Cleveland Clinic Florida, 2950 Cleveland Clinic Blvd, Fl 3, Weston, FL 33331, USACenter for Neurological Restoration, Cleveland Clinic, 9500 Euclid Avenue, Mail Code U2, Cleveland, OH 44195, USACenter for Neurological Restoration, Cleveland Clinic, 9500 Euclid Avenue, Mail Code U2, Cleveland, OH 44195, USACenter for Neurological Restoration, Cleveland Clinic, 9500 Euclid Avenue, Mail Code U2, Cleveland, OH 44195, USACenter for Neurological Restoration, Cleveland Clinic, 9500 Euclid Avenue, Mail Code U2, Cleveland, OH 44195, USACenter for Neurological Restoration, Cleveland Clinic, 9500 Euclid Avenue, Mail Code U2, Cleveland, OH 44195, USACenter for Neurological Restoration, Cleveland Clinic, 9500 Euclid Avenue, Mail Code U2, Cleveland, OH 44195, USADepartment of Neurology, Alexandria University, El Hadara University Hospital, El Hadara Kebly, Alexandria, EgyptDepartment of Neurology, Alexandria University, El Hadara University Hospital, El Hadara Kebly, Alexandria, EgyptDepartment of Neurology, Alexandria University, El Hadara University Hospital, El Hadara Kebly, Alexandria, EgyptCenter for Neurological Restoration, Cleveland Clinic, 9500 Euclid Avenue, Mail Code U2, Cleveland, OH 44195, USACenter for Neurological Restoration, Cleveland Clinic, 9500 Euclid Avenue, Mail Code U2, Cleveland, OH 44195, USAObjective. The primary objective was to evaluate predictors of quality of life (QOL) and functional outcomes following deep brain stimulation (DBS) in Parkinson’s disease (PD) patients. The secondary objective was to identify predictors of global improvement. Methods. PD patients who underwent DBS at our Center from 2006 to 2011 were evaluated by chart review and email/phone survey. Postoperative UPDRS II and EQ-5D were analyzed using simple linear regression adjusting for preoperative score. For global outcomes, we utilized the Patient Global Impression of Change Scale (PGIS) and the Clinician Global Impression of Change Scale (CGIS). Results. There were 130 patients in the dataset. Preoperative and postoperative UPDRS II and EQ-5D were available for 45 patients, PGIS for 67 patients, and CGIS for 116 patients. Patients with falls/postural instability had 6-month functional scores and 1-year QOL scores that were significantly worse than patients without falls/postural instability. For every 1-point increase in preoperative UPDRS III and for every 1-unit increase in body mass index (BMI), the 6-month functional scores significantly worsened. Patients with tremors, without dyskinesia, and without gait-freezing were more likely to have “much” or “very much” improved CGIS. Conclusions. Presence of postural instability, high BMI, and worse baseline motor scores were the greatest predictors of poorer functional and QOL outcomes after DBS.http://dx.doi.org/10.1155/2017/5609163 |
| spellingShingle | Hesham Abboud Gencer Genc Nicolas R. Thompson Srivadee Oravivattanakul Faisal Alsallom Dennys Reyes Kathy Wilson Russell Cerejo Xin Xin Yu Darlene Floden Anwar Ahmed Michal Gostkowski Ayman Ezzeldin Hazem Marouf Ossama Y. Mansour Andre Machado Hubert H. Fernandez Predictors of Functional and Quality of Life Outcomes following Deep Brain Stimulation Surgery in Parkinson’s Disease Patients: Disease, Patient, and Surgical Factors Parkinson's Disease |
| title | Predictors of Functional and Quality of Life Outcomes following Deep Brain Stimulation Surgery in Parkinson’s Disease Patients: Disease, Patient, and Surgical Factors |
| title_full | Predictors of Functional and Quality of Life Outcomes following Deep Brain Stimulation Surgery in Parkinson’s Disease Patients: Disease, Patient, and Surgical Factors |
| title_fullStr | Predictors of Functional and Quality of Life Outcomes following Deep Brain Stimulation Surgery in Parkinson’s Disease Patients: Disease, Patient, and Surgical Factors |
| title_full_unstemmed | Predictors of Functional and Quality of Life Outcomes following Deep Brain Stimulation Surgery in Parkinson’s Disease Patients: Disease, Patient, and Surgical Factors |
| title_short | Predictors of Functional and Quality of Life Outcomes following Deep Brain Stimulation Surgery in Parkinson’s Disease Patients: Disease, Patient, and Surgical Factors |
| title_sort | predictors of functional and quality of life outcomes following deep brain stimulation surgery in parkinson s disease patients disease patient and surgical factors |
| url | http://dx.doi.org/10.1155/2017/5609163 |
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