Analyzing the relationship between gene expression and phenotype in space-flown mice using a causal inference machine learning ensemble

Analyzing the relationship between gene expression and phenotype in space-flown mice using a causal inference machine learning ensemble

Abstract Spaceflight has several detrimental effects on human and rodent health. For example, liver dysfunction is a common phenotype observed in space-flown rodents, and this dysfunction is partially reflected in transcriptomic changes. Studies linking transcriptomics with liver dysfunction rely on...

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Main Authors: James A. Casaletto, Ryan T. Scott, Makenna Myrick, Graham Mackintosh, Hamed Chok, Amanda Saravia-Butler, Adrienne Hoarfrost, Jonathan M. Galazka, Lauren M. Sanders, Sylvain V. Costes
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-024-81394-y
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https://doi.org/10.1038/s41598-024-81394-y

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