Carfilzomib modulates tumor microenvironment to potentiate immune checkpoint therapy for cancer

Carfilzomib modulates tumor microenvironment to potentiate immune checkpoint therapy for cancer

Abstract Impressive clinical benefit is seen in clinic with PD‐1 inhibitors on portion of cancer patients. Yet, there remains an urgent need to develop effective synergizers to expand their clinical application. Tumor‐associated macrophage (TAM), a type of M2‐polarized macrophage, eliminates or supp...

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Bibliographic Details
Main Authors: Qian Zhou, Jinxia Liang, Tong Yang, Jin Liu, Bo Li, Yingchang Li, Zhenzhen Fan, Weida Wang, Wensheng Chen, Sujing Yuan, Meng Xu, Qigui Xu, Zhidong Luan, Zhongjun Xia, Penghui Zhou, Yadong Huang, Liang Chen
Format: Article
Language:English
Published: Springer Nature 2021-12-01
Series:EMBO Molecular Medicine
Subjects:
immunotherapy
M1 macrophage
M2 macrophage
tumor microenvironment
tumor‐associated macrophage
Online Access:https://doi.org/10.15252/emmm.202114502
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https://doi.org/10.15252/emmm.202114502

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