Age-related mitochondrial DNA depletion and the impact on pancreatic Beta cell function.

Age-related mitochondrial DNA depletion and the impact on pancreatic Beta cell function.

Type 2 diabetes is characterised by an age-related decline in insulin secretion. We previously identified a 50% age-related decline in mitochondrial DNA (mtDNA) copy number in isolated human islets. The purpose of this study was to mimic this degree of mtDNA depletion in MIN6 cells to determine whet...

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Main Authors: Donna L Nile, Audrey E Brown, Meutia A Kumaheri, Helen R Blair, Alison Heggie, Satomi Miwa, Lynsey M Cree, Brendan Payne, Patrick F Chinnery, Louise Brown, David A Gunn, Mark Walker
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0115433
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