Exenatide Treatment Causes Suppression of Serum Ghrelin Levels following Mixed Meal Test in Obese Diabetic Women
Aim. To investigate the effect of exenatide treatment on serum ghrelin levels in obese female patients with type 2 diabetes mellitus. Methods. Fourteen female patients with type 2 diabetes mellitus being treated with metformin and exenatide were enrolled. A mixed meal test was applied to the patient...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2016/1309502 |
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| author | Figen Topyildiz Sinem Kiyici Zulfiye Gul Deniz Sigirli Metin Guclu Gurcan Kisakol Sinan Cavun |
| author_facet | Figen Topyildiz Sinem Kiyici Zulfiye Gul Deniz Sigirli Metin Guclu Gurcan Kisakol Sinan Cavun |
| author_sort | Figen Topyildiz |
| collection | DOAJ |
| description | Aim. To investigate the effect of exenatide treatment on serum ghrelin levels in obese female patients with type 2 diabetes mellitus. Methods. Fourteen female patients with type 2 diabetes mellitus being treated with metformin and exenatide were enrolled. A mixed meal test was applied to the patients while continuing with their daily medications. Blood samples were taken before and at 60, 120, and 180 minutes following mixed meal test to measure serum total ghrelin, glucose, and insulin levels. The following week, exenatide treatment of the patients was paused for 24 hours and the same experimental procedures were repeated. Results. Serum ghrelin levels were suppressed significantly at 180 minutes with exenatide treatment compared with baseline (294.4±57.5 versus 234.5±59.4 pg/mL) (p<0.001). Serum ghrelin levels at 180 minutes were statistically different when percentage change in serum ghrelin levels after mixed meal tests with and without exenatide usage were compared (p=0.001). Estimated total area under the curve values for serum ghrelin concentrations was also significantly lower with exenatide compared with omitted treatment (p=0.035). Conclusion. These results suggest that the effect of exenatide on weight loss may be related with the suppression of serum ghrelin levels, which is an orexigenic peptide. |
| format | Article |
| id | doaj-art-a5ca06e7313045ef823e09edd1834db3 |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-a5ca06e7313045ef823e09edd1834db32025-02-03T05:58:59ZengWileyJournal of Diabetes Research2314-67452314-67532016-01-01201610.1155/2016/13095021309502Exenatide Treatment Causes Suppression of Serum Ghrelin Levels following Mixed Meal Test in Obese Diabetic WomenFigen Topyildiz0Sinem Kiyici1Zulfiye Gul2Deniz Sigirli3Metin Guclu4Gurcan Kisakol5Sinan Cavun6Bursa Yuksek Ihtisas Education and Research Hospital, Department of Internal Medicine, 16330 Bursa, TurkeyBursa Yuksek Ihtisas Education and Research Hospital, Department of Internal Medicine, 16330 Bursa, TurkeyUludag University Medical Faculty, Department of Pharmacology, 16059 Bursa, TurkeyUludag University Medical Faculty, Department of Bio-Statistics, 16059 Bursa, TurkeyBursa Yuksek Ihtisas Education and Research Hospital, Department of Endocrinology and Metabolism, 16330 Bursa, TurkeyBursa Yuksek Ihtisas Education and Research Hospital, Department of Endocrinology and Metabolism, 16330 Bursa, TurkeyUludag University Medical Faculty, Department of Pharmacology, 16059 Bursa, TurkeyAim. To investigate the effect of exenatide treatment on serum ghrelin levels in obese female patients with type 2 diabetes mellitus. Methods. Fourteen female patients with type 2 diabetes mellitus being treated with metformin and exenatide were enrolled. A mixed meal test was applied to the patients while continuing with their daily medications. Blood samples were taken before and at 60, 120, and 180 minutes following mixed meal test to measure serum total ghrelin, glucose, and insulin levels. The following week, exenatide treatment of the patients was paused for 24 hours and the same experimental procedures were repeated. Results. Serum ghrelin levels were suppressed significantly at 180 minutes with exenatide treatment compared with baseline (294.4±57.5 versus 234.5±59.4 pg/mL) (p<0.001). Serum ghrelin levels at 180 minutes were statistically different when percentage change in serum ghrelin levels after mixed meal tests with and without exenatide usage were compared (p=0.001). Estimated total area under the curve values for serum ghrelin concentrations was also significantly lower with exenatide compared with omitted treatment (p=0.035). Conclusion. These results suggest that the effect of exenatide on weight loss may be related with the suppression of serum ghrelin levels, which is an orexigenic peptide.http://dx.doi.org/10.1155/2016/1309502 |
| spellingShingle | Figen Topyildiz Sinem Kiyici Zulfiye Gul Deniz Sigirli Metin Guclu Gurcan Kisakol Sinan Cavun Exenatide Treatment Causes Suppression of Serum Ghrelin Levels following Mixed Meal Test in Obese Diabetic Women Journal of Diabetes Research |
| title | Exenatide Treatment Causes Suppression of Serum Ghrelin Levels following Mixed Meal Test in Obese Diabetic Women |
| title_full | Exenatide Treatment Causes Suppression of Serum Ghrelin Levels following Mixed Meal Test in Obese Diabetic Women |
| title_fullStr | Exenatide Treatment Causes Suppression of Serum Ghrelin Levels following Mixed Meal Test in Obese Diabetic Women |
| title_full_unstemmed | Exenatide Treatment Causes Suppression of Serum Ghrelin Levels following Mixed Meal Test in Obese Diabetic Women |
| title_short | Exenatide Treatment Causes Suppression of Serum Ghrelin Levels following Mixed Meal Test in Obese Diabetic Women |
| title_sort | exenatide treatment causes suppression of serum ghrelin levels following mixed meal test in obese diabetic women |
| url | http://dx.doi.org/10.1155/2016/1309502 |
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