Neurological Complications of Middle East Respiratory Syndrome Coronavirus: A Report of Two Cases and Review of the Literature
Middle East Respiratory Syndrome Coronavirus (MERS-CoV) was first discovered in September 2012 in Saudi Arabia. Since then, it caused more than 1600 laboratory-confirmed cases and more than 580 deaths among them. The clinical course of the disease ranges from asymptomatic infection to severe lower r...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Case Reports in Neurological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2016/3502683 |
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| author | Hussein Algahtani Ahmad Subahi Bader Shirah |
| author_facet | Hussein Algahtani Ahmad Subahi Bader Shirah |
| author_sort | Hussein Algahtani |
| collection | DOAJ |
| description | Middle East Respiratory Syndrome Coronavirus (MERS-CoV) was first discovered in September 2012 in Saudi Arabia. Since then, it caused more than 1600 laboratory-confirmed cases and more than 580 deaths among them. The clinical course of the disease ranges from asymptomatic infection to severe lower respiratory tract illness with multiorgan involvement and death. The disease can cause pulmonary, renal, hematological, and gastrointestinal complications. In this paper, we report neurological complications of MERS-CoV in two adult patients, and we hypothesize the pathophysiology. The first patient had an intracerebral hemorrhage as a result of thrombocytopenia, disseminated intravascular coagulation, and platelet dysfunction. The second case was a case of critical illness polyneuropathy complicating a long ICU stay. In these cases, the neurological complications were secondary to systemic complications and long ICU stay. Autopsy studies are needed to further understand the pathological mechanism. |
| format | Article |
| id | doaj-art-a5c05a75d14e4b0381113c021a53323c |
| institution | Kabale University |
| issn | 2090-6668 2090-6676 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Neurological Medicine |
| spelling | doaj-art-a5c05a75d14e4b0381113c021a53323c2025-02-03T01:09:47ZengWileyCase Reports in Neurological Medicine2090-66682090-66762016-01-01201610.1155/2016/35026833502683Neurological Complications of Middle East Respiratory Syndrome Coronavirus: A Report of Two Cases and Review of the LiteratureHussein Algahtani0Ahmad Subahi1Bader Shirah2King Abdulaziz Medical City/King Saud bin Abdulaziz University for Health Sciences, P.O. Box 12723, Jeddah 21483, Saudi ArabiaKing Saud bin Abdulaziz University for Health Sciences, P.O. Box 12723, Jeddah 21483, Saudi ArabiaKing Abdullah International Medical Research Center/King Saud bin Abdulaziz University for Health Sciences, P.O. Box 12723, Jeddah 21483, Saudi ArabiaMiddle East Respiratory Syndrome Coronavirus (MERS-CoV) was first discovered in September 2012 in Saudi Arabia. Since then, it caused more than 1600 laboratory-confirmed cases and more than 580 deaths among them. The clinical course of the disease ranges from asymptomatic infection to severe lower respiratory tract illness with multiorgan involvement and death. The disease can cause pulmonary, renal, hematological, and gastrointestinal complications. In this paper, we report neurological complications of MERS-CoV in two adult patients, and we hypothesize the pathophysiology. The first patient had an intracerebral hemorrhage as a result of thrombocytopenia, disseminated intravascular coagulation, and platelet dysfunction. The second case was a case of critical illness polyneuropathy complicating a long ICU stay. In these cases, the neurological complications were secondary to systemic complications and long ICU stay. Autopsy studies are needed to further understand the pathological mechanism.http://dx.doi.org/10.1155/2016/3502683 |
| spellingShingle | Hussein Algahtani Ahmad Subahi Bader Shirah Neurological Complications of Middle East Respiratory Syndrome Coronavirus: A Report of Two Cases and Review of the Literature Case Reports in Neurological Medicine |
| title | Neurological Complications of Middle East Respiratory Syndrome Coronavirus: A Report of Two Cases and Review of the Literature |
| title_full | Neurological Complications of Middle East Respiratory Syndrome Coronavirus: A Report of Two Cases and Review of the Literature |
| title_fullStr | Neurological Complications of Middle East Respiratory Syndrome Coronavirus: A Report of Two Cases and Review of the Literature |
| title_full_unstemmed | Neurological Complications of Middle East Respiratory Syndrome Coronavirus: A Report of Two Cases and Review of the Literature |
| title_short | Neurological Complications of Middle East Respiratory Syndrome Coronavirus: A Report of Two Cases and Review of the Literature |
| title_sort | neurological complications of middle east respiratory syndrome coronavirus a report of two cases and review of the literature |
| url | http://dx.doi.org/10.1155/2016/3502683 |
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