Lactylation of HDAC1 Confers Resistance to Ferroptosis in Colorectal Cancer

Lactylation of HDAC1 Confers Resistance to Ferroptosis in Colorectal Cancer

Abstract Colorectal cancer (CRC) is highly resistant to ferroptosis, which hinders the application of anti‐ferroptosis therapy. Through drug screening, it is found that histone deacetylase inhibitor (HDACi) significantly sensitized CRC to ferroptosis. The combination of HDACi and ferroptosis inducer...

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Main Authors: Zhou Yang, Wei Su, Qinglin Zhang, Lili Niu, Baijie Feng, Yu Zhang, Feng Huang, Jiaxin He, Qinyao Zhou, Xin Zhou, Longjun Ma, Jingwan Zhou, Yuanrong Wang, Wenjing Xiong, Jun Xiang, Zhilin Hu, Qiang Zhan, Bing Yao
Format: Article
Language:English
Published: Wiley 2025-03-01
Series:Advanced Science
Subjects:
colorectal cancer
ferroptosis
HDAC inhibitor
lactylation
N6‐methyladenosine modification
Online Access:https://doi.org/10.1002/advs.202408845
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https://doi.org/10.1002/advs.202408845

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