Self-Emulsifying Drug Delivery Systems (SEDDS): Transition from Liquid to Solid—A Comprehensive Review of Formulation, Characterization, Applications, and Future Trends
Self-emulsifying drug delivery systems (SEDDS) represent an innovative approach to improving the solubility and bioavailability of poorly water-soluble drugs, addressing significant challenges associated with oral drug delivery. This review highlights the advancements and applications of SEDDS, incl...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-01-01
|
| Series: | Pharmaceutics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4923/17/1/63 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832587729445060608 |
|---|---|
| author | Prateek Uttreja Indrajeet Karnik Ahmed Adel Ali Youssef Nagarjuna Narala Rasha M. Elkanayati Srikanth Baisa Nouf D. Alshammari Srikanth Banda Sateesh Kumar Vemula Michael A. Repka |
| author_facet | Prateek Uttreja Indrajeet Karnik Ahmed Adel Ali Youssef Nagarjuna Narala Rasha M. Elkanayati Srikanth Baisa Nouf D. Alshammari Srikanth Banda Sateesh Kumar Vemula Michael A. Repka |
| author_sort | Prateek Uttreja |
| collection | DOAJ |
| description | Self-emulsifying drug delivery systems (SEDDS) represent an innovative approach to improving the solubility and bioavailability of poorly water-soluble drugs, addressing significant challenges associated with oral drug delivery. This review highlights the advancements and applications of SEDDS, including their transition from liquid to solid forms, while addressing the formulation strategies, characterization techniques, and future prospects in pharmaceutical sciences. The review systematically analyzes existing studies on SEDDS, focusing on their classification into liquid and solid forms and their preparation methods, including spray drying, hot-melt extrusion, and adsorption onto carriers. Characterization techniques such as droplet size analysis, dissolution studies, and solid-state evaluations are detailed. Additionally, emerging trends, including 3D printing, hybrid systems, and supersaturable SEDDS (Su-SEDDS), are explored. Liquid SEDDS (L-SEDDS) enhance drug solubility and absorption by forming emulsions upon contact with gastrointestinal fluids. However, they suffer from stability and leakage issues. Transitioning to solid SEDDS (S-SEDDS) has resolved these limitations, offering enhanced stability, scalability, and patient compliance. Innovations such as personalized 3D-printed SEDDS, biologics delivery, and targeted systems demonstrate their potential for diverse therapeutic applications. Computational modeling and in silico approaches further accelerate formulation optimization. SEDDS have revolutionized drug delivery by improving bioavailability and enabling precise, patient-centric therapies. While challenges such as scalability and excipient toxicity persist, emerging technologies and multidisciplinary collaborations are paving the way for next-generation SEDDS. Their adaptability and potential for personalized medicine solidify their role as a cornerstone in modern pharmaceutical development. |
| format | Article |
| id | doaj-art-a56c38f0a79f47728c27e951c901cd54 |
| institution | Kabale University |
| issn | 1999-4923 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj-art-a56c38f0a79f47728c27e951c901cd542025-01-24T13:45:47ZengMDPI AGPharmaceutics1999-49232025-01-011716310.3390/pharmaceutics17010063Self-Emulsifying Drug Delivery Systems (SEDDS): Transition from Liquid to Solid—A Comprehensive Review of Formulation, Characterization, Applications, and Future TrendsPrateek Uttreja0Indrajeet Karnik1Ahmed Adel Ali Youssef2Nagarjuna Narala3Rasha M. Elkanayati4Srikanth Baisa5Nouf D. Alshammari6Srikanth Banda7Sateesh Kumar Vemula8Michael A. Repka9Department of Pharmaceutics and Drug Delivery, School of Pharmacy, The University of Mississippi, Oxford, MS 38677, USADepartment of Pharmaceutics and Drug Delivery, School of Pharmacy, The University of Mississippi, Oxford, MS 38677, USADepartment of Pharmaceutical Technology, Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh 33516, EgyptDepartment of Pharmaceutics and Drug Delivery, School of Pharmacy, The University of Mississippi, Oxford, MS 38677, USADepartment of Pharmaceutics and Drug Delivery, School of Pharmacy, The University of Mississippi, Oxford, MS 38677, USADepartment of Pharmaceutics and Drug Delivery, School of Pharmacy, The University of Mississippi, Oxford, MS 38677, USADepartment of Pharmaceutics and Drug Delivery, School of Pharmacy, The University of Mississippi, Oxford, MS 38677, USADepartment of Chemistry and Biochemistry, Florida International University, Miami, FL 33199, USADepartment of Pharmaceutics and Drug Delivery, School of Pharmacy, The University of Mississippi, Oxford, MS 38677, USADepartment of Pharmaceutics and Drug Delivery, School of Pharmacy, The University of Mississippi, Oxford, MS 38677, USASelf-emulsifying drug delivery systems (SEDDS) represent an innovative approach to improving the solubility and bioavailability of poorly water-soluble drugs, addressing significant challenges associated with oral drug delivery. This review highlights the advancements and applications of SEDDS, including their transition from liquid to solid forms, while addressing the formulation strategies, characterization techniques, and future prospects in pharmaceutical sciences. The review systematically analyzes existing studies on SEDDS, focusing on their classification into liquid and solid forms and their preparation methods, including spray drying, hot-melt extrusion, and adsorption onto carriers. Characterization techniques such as droplet size analysis, dissolution studies, and solid-state evaluations are detailed. Additionally, emerging trends, including 3D printing, hybrid systems, and supersaturable SEDDS (Su-SEDDS), are explored. Liquid SEDDS (L-SEDDS) enhance drug solubility and absorption by forming emulsions upon contact with gastrointestinal fluids. However, they suffer from stability and leakage issues. Transitioning to solid SEDDS (S-SEDDS) has resolved these limitations, offering enhanced stability, scalability, and patient compliance. Innovations such as personalized 3D-printed SEDDS, biologics delivery, and targeted systems demonstrate their potential for diverse therapeutic applications. Computational modeling and in silico approaches further accelerate formulation optimization. SEDDS have revolutionized drug delivery by improving bioavailability and enabling precise, patient-centric therapies. While challenges such as scalability and excipient toxicity persist, emerging technologies and multidisciplinary collaborations are paving the way for next-generation SEDDS. Their adaptability and potential for personalized medicine solidify their role as a cornerstone in modern pharmaceutical development.https://www.mdpi.com/1999-4923/17/1/63self-emulsifying drug delivery systemsSEDDSbioavailability enhancementlipid-based drug delivery systemsSNEDDSsolid SEDDS |
| spellingShingle | Prateek Uttreja Indrajeet Karnik Ahmed Adel Ali Youssef Nagarjuna Narala Rasha M. Elkanayati Srikanth Baisa Nouf D. Alshammari Srikanth Banda Sateesh Kumar Vemula Michael A. Repka Self-Emulsifying Drug Delivery Systems (SEDDS): Transition from Liquid to Solid—A Comprehensive Review of Formulation, Characterization, Applications, and Future Trends Pharmaceutics self-emulsifying drug delivery systems SEDDS bioavailability enhancement lipid-based drug delivery systems SNEDDS solid SEDDS |
| title | Self-Emulsifying Drug Delivery Systems (SEDDS): Transition from Liquid to Solid—A Comprehensive Review of Formulation, Characterization, Applications, and Future Trends |
| title_full | Self-Emulsifying Drug Delivery Systems (SEDDS): Transition from Liquid to Solid—A Comprehensive Review of Formulation, Characterization, Applications, and Future Trends |
| title_fullStr | Self-Emulsifying Drug Delivery Systems (SEDDS): Transition from Liquid to Solid—A Comprehensive Review of Formulation, Characterization, Applications, and Future Trends |
| title_full_unstemmed | Self-Emulsifying Drug Delivery Systems (SEDDS): Transition from Liquid to Solid—A Comprehensive Review of Formulation, Characterization, Applications, and Future Trends |
| title_short | Self-Emulsifying Drug Delivery Systems (SEDDS): Transition from Liquid to Solid—A Comprehensive Review of Formulation, Characterization, Applications, and Future Trends |
| title_sort | self emulsifying drug delivery systems sedds transition from liquid to solid a comprehensive review of formulation characterization applications and future trends |
| topic | self-emulsifying drug delivery systems SEDDS bioavailability enhancement lipid-based drug delivery systems SNEDDS solid SEDDS |
| url | https://www.mdpi.com/1999-4923/17/1/63 |
| work_keys_str_mv | AT prateekuttreja selfemulsifyingdrugdeliverysystemsseddstransitionfromliquidtosolidacomprehensivereviewofformulationcharacterizationapplicationsandfuturetrends AT indrajeetkarnik selfemulsifyingdrugdeliverysystemsseddstransitionfromliquidtosolidacomprehensivereviewofformulationcharacterizationapplicationsandfuturetrends AT ahmedadelaliyoussef selfemulsifyingdrugdeliverysystemsseddstransitionfromliquidtosolidacomprehensivereviewofformulationcharacterizationapplicationsandfuturetrends AT nagarjunanarala selfemulsifyingdrugdeliverysystemsseddstransitionfromliquidtosolidacomprehensivereviewofformulationcharacterizationapplicationsandfuturetrends AT rashamelkanayati selfemulsifyingdrugdeliverysystemsseddstransitionfromliquidtosolidacomprehensivereviewofformulationcharacterizationapplicationsandfuturetrends AT srikanthbaisa selfemulsifyingdrugdeliverysystemsseddstransitionfromliquidtosolidacomprehensivereviewofformulationcharacterizationapplicationsandfuturetrends AT noufdalshammari selfemulsifyingdrugdeliverysystemsseddstransitionfromliquidtosolidacomprehensivereviewofformulationcharacterizationapplicationsandfuturetrends AT srikanthbanda selfemulsifyingdrugdeliverysystemsseddstransitionfromliquidtosolidacomprehensivereviewofformulationcharacterizationapplicationsandfuturetrends AT sateeshkumarvemula selfemulsifyingdrugdeliverysystemsseddstransitionfromliquidtosolidacomprehensivereviewofformulationcharacterizationapplicationsandfuturetrends AT michaelarepka selfemulsifyingdrugdeliverysystemsseddstransitionfromliquidtosolidacomprehensivereviewofformulationcharacterizationapplicationsandfuturetrends |