Emerging Lung Cancer Therapeutic Targets Based on the Pathogenesis of Bone Metastases
Lung cancer is the second most common cancer and the leading cause of cancer related mortality in both men and women. Each year, more people die of lung cancer than of colon, breast, and prostate cancers combined. It is widely accepted that tumor metastasis is a formidable barrier to effective treat...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | International Journal of Cell Biology |
| Online Access: | http://dx.doi.org/10.1155/2014/236246 |
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| _version_ | 1832548138855956480 |
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| author | Moses O. Oyewumi Adnan Alazizi Daniel Wehrung Rami Manochakian Fayez F. Safadi |
| author_facet | Moses O. Oyewumi Adnan Alazizi Daniel Wehrung Rami Manochakian Fayez F. Safadi |
| author_sort | Moses O. Oyewumi |
| collection | DOAJ |
| description | Lung cancer is the second most common cancer and the leading cause of cancer related mortality in both men and women. Each year, more people die of lung cancer than of colon, breast, and prostate cancers combined. It is widely accepted that tumor metastasis is a formidable barrier to effective treatment of lung cancer. The bone is one of the frequent metastatic sites for lung cancer occurring in a large number of patients. Bone metastases can cause a wide range of symptoms that could impair quality of life of lung cancer patients and shorten their survival. We strongly believe that molecular targets (tumor-related and bone microenvironment based) that have been implicated in lung cancer bone metastases hold great promise in lung cancer therapeutics. Thus, this paper discusses some of the emerging molecular targets that have provided insights into the cascade of metastases in lung cancer with the focus on bone invasion. It is anticipated that the information gathered might be useful in future efforts of optimizing lung cancer treatment strategies. |
| format | Article |
| id | doaj-art-a539891ab11147d0983225a86770a7c3 |
| institution | Kabale University |
| issn | 1687-8876 1687-8884 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Cell Biology |
| spelling | doaj-art-a539891ab11147d0983225a86770a7c32025-02-03T06:42:05ZengWileyInternational Journal of Cell Biology1687-88761687-88842014-01-01201410.1155/2014/236246236246Emerging Lung Cancer Therapeutic Targets Based on the Pathogenesis of Bone MetastasesMoses O. Oyewumi0Adnan Alazizi1Daniel Wehrung2Rami Manochakian3Fayez F. Safadi4Department of Pharmaceutical Sciences, College of Pharmacy, Northeast Ohio Medical University, Rootstown, OH 44272, USADepartment of Pharmaceutical Sciences, College of Pharmacy, Northeast Ohio Medical University, Rootstown, OH 44272, USADepartment of Pharmaceutical Sciences, College of Pharmacy, Northeast Ohio Medical University, Rootstown, OH 44272, USADivision of Hematology/Oncology, Department of Medicine, Case Western Reserve University, Louis Stokes Veteran Affairs Medical Center, Cleveland, OH 44106, USADepartment of Anatomy and Neurobiology, College of Medicine, Northeast Ohio Medical University, Rootstown, OH 44272, USALung cancer is the second most common cancer and the leading cause of cancer related mortality in both men and women. Each year, more people die of lung cancer than of colon, breast, and prostate cancers combined. It is widely accepted that tumor metastasis is a formidable barrier to effective treatment of lung cancer. The bone is one of the frequent metastatic sites for lung cancer occurring in a large number of patients. Bone metastases can cause a wide range of symptoms that could impair quality of life of lung cancer patients and shorten their survival. We strongly believe that molecular targets (tumor-related and bone microenvironment based) that have been implicated in lung cancer bone metastases hold great promise in lung cancer therapeutics. Thus, this paper discusses some of the emerging molecular targets that have provided insights into the cascade of metastases in lung cancer with the focus on bone invasion. It is anticipated that the information gathered might be useful in future efforts of optimizing lung cancer treatment strategies.http://dx.doi.org/10.1155/2014/236246 |
| spellingShingle | Moses O. Oyewumi Adnan Alazizi Daniel Wehrung Rami Manochakian Fayez F. Safadi Emerging Lung Cancer Therapeutic Targets Based on the Pathogenesis of Bone Metastases International Journal of Cell Biology |
| title | Emerging Lung Cancer Therapeutic Targets Based on the Pathogenesis of Bone Metastases |
| title_full | Emerging Lung Cancer Therapeutic Targets Based on the Pathogenesis of Bone Metastases |
| title_fullStr | Emerging Lung Cancer Therapeutic Targets Based on the Pathogenesis of Bone Metastases |
| title_full_unstemmed | Emerging Lung Cancer Therapeutic Targets Based on the Pathogenesis of Bone Metastases |
| title_short | Emerging Lung Cancer Therapeutic Targets Based on the Pathogenesis of Bone Metastases |
| title_sort | emerging lung cancer therapeutic targets based on the pathogenesis of bone metastases |
| url | http://dx.doi.org/10.1155/2014/236246 |
| work_keys_str_mv | AT mosesooyewumi emerginglungcancertherapeutictargetsbasedonthepathogenesisofbonemetastases AT adnanalazizi emerginglungcancertherapeutictargetsbasedonthepathogenesisofbonemetastases AT danielwehrung emerginglungcancertherapeutictargetsbasedonthepathogenesisofbonemetastases AT ramimanochakian emerginglungcancertherapeutictargetsbasedonthepathogenesisofbonemetastases AT fayezfsafadi emerginglungcancertherapeutictargetsbasedonthepathogenesisofbonemetastases |