Cited4 is a sex‐biased mediator of the antidiabetic glitazone response in adipocyte progenitors

Cited4 is a sex‐biased mediator of the antidiabetic glitazone response in adipocyte progenitors

Abstract Most antidiabetic drugs treat disease symptoms rather than adipose tissue dysfunction as a key pathogenic cause in the metabolic syndrome and type 2 diabetes. Pharmacological targeting of adipose tissue through the nuclear receptor PPARg, as exemplified by glitazone treatments, mediates eff...

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Main Authors: Irem Bayindir‐Buchhalter, Gretchen Wolff, Sarah Lerch, Tjeerd Sijmonsma, Maximilian Schuster, Jan Gronych, Adrian T Billeter, Rohollah Babaei, Damir Krunic, Lars Ketscher, Nadine Spielmann, Martin Hrabe de Angelis, Jorge L Ruas, Beat P Müller‐Stich, Mathias Heikenwalder, Peter Lichter, Stephan Herzig, Alexandros Vegiopoulos
Format: Article
Language:English
Published: Springer Nature 2018-07-01
Series:EMBO Molecular Medicine
Subjects:
adipocyte progenitors
browning
Cited4
glitazones
insulin sensitivity
Online Access:https://doi.org/10.15252/emmm.201708613
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https://doi.org/10.15252/emmm.201708613

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