Piezo1 activation protects against sepsis-induced myocardial dysfunction in a pilot study

Piezo1 activation protects against sepsis-induced myocardial dysfunction in a pilot study

Abstract To explore the role and underlying mechanisms of Piezo1 in sepsis-induced myocardial dysfunction (SIMD). A SIMD model was established in mice via intraperitoneal lipopolysaccharide (LPS) injection. Cardiac function, histology, Piezo1 protein expression, and cardiac troponin T (cTnT) were as...

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Bibliographic Details
Main Authors: Angwei Gong, Jing Dai, Yan Zhao, Haijuan Hu, Chengjian Guan, Hangtian Yu, Keke Wang, Sheng Jin, Yuming Wu, Bing Xiao
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Subjects:
Piezo1
Sepsis
SIMD
DUSP3
Online Access:https://doi.org/10.1038/s41598-025-00829-2
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https://doi.org/10.1038/s41598-025-00829-2

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