A novel polypeptide encoded by circSPIRE1 promotes prostate cancer proliferation and migration by restraining the ubiquitin-dependent degradation of LRP5

A novel polypeptide encoded by circSPIRE1 promotes prostate cancer proliferation and migration by restraining the ubiquitin-dependent degradation of LRP5

Abstract Background Circular RNAs (circRNAs) are increasingly implicated in tumor progression, but the roles of protein-coding circRNAs remain largely unexplored. This study characterizes a novel circRNA-encoded protein, rtSPIRE1, and investigates its mechanistic role in prostate cancer proliferatio...

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Main Authors: Jintao Hu, Juanyi Shi, Junjie Wang, Yunfei Xiao, Degeng Kong, Mingchao Gao, Tianlong Luo, Shizhong Xu, Zhihan Yuan, Xinyi Ma, Xueseng Dong, Jingang Huang, Cheng Liu, Kewei Xu
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
circSPIRE1
Rolling circle translation
Peptide
hnRNPA1
Proliferation
Migration
Online Access:https://doi.org/10.1186/s13046-025-03467-8
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https://doi.org/10.1186/s13046-025-03467-8

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