Clinical significance of serum cystatin C‐to‐creatinine ratio as a surrogate marker for incident osteoporotic fracture predictions
Abstract Background Detection of appropriate indicators is valuable for preventing incidental osteoporotic fractures. We statistically evaluated the significance of serum cystatin C‐to‐creatinine ratio (CysC/Cr) as a surrogate marker for incident major osteoporotic fractures (MOF) prediction. Method...
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Wiley
2023-05-01
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| Series: | Journal of General and Family Medicine |
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| Online Access: | https://doi.org/10.1002/jgf2.618 |
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| author | Ichiro Yoshii Naoya Sawada Tatsumi Chijiwa |
| author_facet | Ichiro Yoshii Naoya Sawada Tatsumi Chijiwa |
| author_sort | Ichiro Yoshii |
| collection | DOAJ |
| description | Abstract Background Detection of appropriate indicators is valuable for preventing incidental osteoporotic fractures. We statistically evaluated the significance of serum cystatin C‐to‐creatinine ratio (CysC/Cr) as a surrogate marker for incident major osteoporotic fractures (MOF) prediction. Methods Eligible patients with simultaneous measurement of CysC/Cr and bone mineral density in the lumbar spine and proximal femur were selected, and their fracture histories until 5 years after baseline were observed in the retrospective area cohort data. Patients who were followed up until termination or the first osteoporotic fracture were included, and loss of follow‐up or death was excluded. Candidate risk factors for osteoporotic fractures were tested for risk ratios using a cox regression analysis. Receiver operating characteristic tests were performed on factors with significantly higher risk ratios and evaluated with Kaplan‐Meier survival analysis to determine the hazard ratios of the factors. Results A total of 175 patients of whom 28 had incident MOF, 38 men, and 137 women, were enrolled. The mean age was 70.2 years. A significantly higher risk ratio was shown in the presence of prevalent MOF, hyper fall‐ability, lifestyle‐related diseases, chronic kidney diseases ≥ Grade3a, and higher CysC/Cr. All parameters had cutoff indices and showed significantly higher hazard ratios. Conclusions These results suggested that CysC/Cr may be a predictive marker of incident osteoporotic fractures. It might work as a screening tool for MOF risk. |
| format | Article |
| id | doaj-art-a4dfc84cdf714c55828fbaf7276c9d35 |
| institution | Kabale University |
| issn | 2189-7948 |
| language | English |
| publishDate | 2023-05-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of General and Family Medicine |
| spelling | doaj-art-a4dfc84cdf714c55828fbaf7276c9d352025-01-28T12:00:52ZengWileyJournal of General and Family Medicine2189-79482023-05-0124317818410.1002/jgf2.618Clinical significance of serum cystatin C‐to‐creatinine ratio as a surrogate marker for incident osteoporotic fracture predictionsIchiro Yoshii0Naoya Sawada1Tatsumi Chijiwa2Department of Musculoskeletal Medicine Yoshii Hospital Shimanto City JapanDepartment of Rheumatology Dohgo Onsen Hospital Rheumatology Center Matsuyama JapanDepartment of Rheumatology Kochi Memorial Hospital Kochi JapanAbstract Background Detection of appropriate indicators is valuable for preventing incidental osteoporotic fractures. We statistically evaluated the significance of serum cystatin C‐to‐creatinine ratio (CysC/Cr) as a surrogate marker for incident major osteoporotic fractures (MOF) prediction. Methods Eligible patients with simultaneous measurement of CysC/Cr and bone mineral density in the lumbar spine and proximal femur were selected, and their fracture histories until 5 years after baseline were observed in the retrospective area cohort data. Patients who were followed up until termination or the first osteoporotic fracture were included, and loss of follow‐up or death was excluded. Candidate risk factors for osteoporotic fractures were tested for risk ratios using a cox regression analysis. Receiver operating characteristic tests were performed on factors with significantly higher risk ratios and evaluated with Kaplan‐Meier survival analysis to determine the hazard ratios of the factors. Results A total of 175 patients of whom 28 had incident MOF, 38 men, and 137 women, were enrolled. The mean age was 70.2 years. A significantly higher risk ratio was shown in the presence of prevalent MOF, hyper fall‐ability, lifestyle‐related diseases, chronic kidney diseases ≥ Grade3a, and higher CysC/Cr. All parameters had cutoff indices and showed significantly higher hazard ratios. Conclusions These results suggested that CysC/Cr may be a predictive marker of incident osteoporotic fractures. It might work as a screening tool for MOF risk.https://doi.org/10.1002/jgf2.618creatininecystatin Cfractureosteoporosisrisk ratiosurrogate marker |
| spellingShingle | Ichiro Yoshii Naoya Sawada Tatsumi Chijiwa Clinical significance of serum cystatin C‐to‐creatinine ratio as a surrogate marker for incident osteoporotic fracture predictions Journal of General and Family Medicine creatinine cystatin C fracture osteoporosis risk ratio surrogate marker |
| title | Clinical significance of serum cystatin C‐to‐creatinine ratio as a surrogate marker for incident osteoporotic fracture predictions |
| title_full | Clinical significance of serum cystatin C‐to‐creatinine ratio as a surrogate marker for incident osteoporotic fracture predictions |
| title_fullStr | Clinical significance of serum cystatin C‐to‐creatinine ratio as a surrogate marker for incident osteoporotic fracture predictions |
| title_full_unstemmed | Clinical significance of serum cystatin C‐to‐creatinine ratio as a surrogate marker for incident osteoporotic fracture predictions |
| title_short | Clinical significance of serum cystatin C‐to‐creatinine ratio as a surrogate marker for incident osteoporotic fracture predictions |
| title_sort | clinical significance of serum cystatin c to creatinine ratio as a surrogate marker for incident osteoporotic fracture predictions |
| topic | creatinine cystatin C fracture osteoporosis risk ratio surrogate marker |
| url | https://doi.org/10.1002/jgf2.618 |
| work_keys_str_mv | AT ichiroyoshii clinicalsignificanceofserumcystatinctocreatinineratioasasurrogatemarkerforincidentosteoporoticfracturepredictions AT naoyasawada clinicalsignificanceofserumcystatinctocreatinineratioasasurrogatemarkerforincidentosteoporoticfracturepredictions AT tatsumichijiwa clinicalsignificanceofserumcystatinctocreatinineratioasasurrogatemarkerforincidentosteoporoticfracturepredictions |