Effects of probiotics and its fermented milk on constipation: a systematic review
This study reviewed clinical evidence of probiotics-mediated effects on constipation. Four databases were used in the literature searches, namely Cochrane Library, Embase, Pubmed, and Web of Science. The last retrieval time was March 2021. Collected data were analyzed by Review Manager (version 5.3)...
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| Format: | Article |
| Language: | English |
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Tsinghua University Press
2023-11-01
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| Series: | Food Science and Human Wellness |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213453023000769 |
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| author | Jiaming Yan Meiling Wu Wei Zhao Lai-Yu Kwok Wenyi Zhang |
| author_facet | Jiaming Yan Meiling Wu Wei Zhao Lai-Yu Kwok Wenyi Zhang |
| author_sort | Jiaming Yan |
| collection | DOAJ |
| description | This study reviewed clinical evidence of probiotics-mediated effects on constipation. Four databases were used in the literature searches, namely Cochrane Library, Embase, Pubmed, and Web of Science. The last retrieval time was March 2021. Collected data were analyzed by Review Manager (version 5.3) and Stata (version 14). The primary search retrieved 8 418 articles after removing duplicates. Eventually, twenty six studies were included in the meta-analysis. Administration of probiotics significantly increased stool frequency (MD: 1.15 times/week; 95 % CI: 0.59 to 1.70; P < 0.000 1), improved bloating (MD: –0.48; 95 % CI: –0.89 to –0.07; P = 0.02), reduced abdominal pain (MD: –0.71; 95 % CI: –1.25 to –0.16; P = 0.01), and improved quality of life (MD: –0.73; 95 % CI: –1.37 to –0.10; P = 0.02). However, the clinical effect of intake of probiotics on stool consistency was non-significant (MD: 0.07; 95 % CI: –0.34 to 0.48; P = 0.73). Based on our analysis, probiotic supplements were effective in relieving constipation through symptom improvement. The effectiveness of dosage forms of intervention ranked: capsules > others (tablets, powder) > fermented milk. |
| format | Article |
| id | doaj-art-a4d1d53f48074ecb960d4d1a6af2565a |
| institution | Kabale University |
| issn | 2213-4530 |
| language | English |
| publishDate | 2023-11-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Food Science and Human Wellness |
| spelling | doaj-art-a4d1d53f48074ecb960d4d1a6af2565a2025-02-03T06:54:16ZengTsinghua University PressFood Science and Human Wellness2213-45302023-11-0112621242134Effects of probiotics and its fermented milk on constipation: a systematic reviewJiaming Yan0Meiling Wu1Wei Zhao2Lai-Yu Kwok3Wenyi Zhang4Key Laboratory of Dairy Biotechnology and Engineering, Ministry of Education, Inner Mongolia Agricultural University, Hohhot 010018, China; Key Laboratory of Dairy Products Processing, Ministry of Agriculture, Inner Mongolia Agricultural University, Hohhot 010018, ChinaKey Laboratory of Dairy Biotechnology and Engineering, Ministry of Education, Inner Mongolia Agricultural University, Hohhot 010018, China; Key Laboratory of Dairy Products Processing, Ministry of Agriculture, Inner Mongolia Agricultural University, Hohhot 010018, ChinaKey Laboratory of Dairy Biotechnology and Engineering, Ministry of Education, Inner Mongolia Agricultural University, Hohhot 010018, China; Key Laboratory of Dairy Products Processing, Ministry of Agriculture, Inner Mongolia Agricultural University, Hohhot 010018, ChinaKey Laboratory of Dairy Biotechnology and Engineering, Ministry of Education, Inner Mongolia Agricultural University, Hohhot 010018, China; Key Laboratory of Dairy Products Processing, Ministry of Agriculture, Inner Mongolia Agricultural University, Hohhot 010018, ChinaKey Laboratory of Dairy Biotechnology and Engineering, Ministry of Education, Inner Mongolia Agricultural University, Hohhot 010018, China; Key Laboratory of Dairy Products Processing, Ministry of Agriculture, Inner Mongolia Agricultural University, Hohhot 010018, China; Corresponding author at: Key Laboratory of Dairy Biotechnology and Engineering, Ministry of Education, Inner Mongolia Agricultural University, Hohhot 010018, China.This study reviewed clinical evidence of probiotics-mediated effects on constipation. Four databases were used in the literature searches, namely Cochrane Library, Embase, Pubmed, and Web of Science. The last retrieval time was March 2021. Collected data were analyzed by Review Manager (version 5.3) and Stata (version 14). The primary search retrieved 8 418 articles after removing duplicates. Eventually, twenty six studies were included in the meta-analysis. Administration of probiotics significantly increased stool frequency (MD: 1.15 times/week; 95 % CI: 0.59 to 1.70; P < 0.000 1), improved bloating (MD: –0.48; 95 % CI: –0.89 to –0.07; P = 0.02), reduced abdominal pain (MD: –0.71; 95 % CI: –1.25 to –0.16; P = 0.01), and improved quality of life (MD: –0.73; 95 % CI: –1.37 to –0.10; P = 0.02). However, the clinical effect of intake of probiotics on stool consistency was non-significant (MD: 0.07; 95 % CI: –0.34 to 0.48; P = 0.73). Based on our analysis, probiotic supplements were effective in relieving constipation through symptom improvement. The effectiveness of dosage forms of intervention ranked: capsules > others (tablets, powder) > fermented milk.http://www.sciencedirect.com/science/article/pii/S2213453023000769ConstipationProbioticsFermented milkMeta-analysisDosage form |
| spellingShingle | Jiaming Yan Meiling Wu Wei Zhao Lai-Yu Kwok Wenyi Zhang Effects of probiotics and its fermented milk on constipation: a systematic review Food Science and Human Wellness Constipation Probiotics Fermented milk Meta-analysis Dosage form |
| title | Effects of probiotics and its fermented milk on constipation: a systematic review |
| title_full | Effects of probiotics and its fermented milk on constipation: a systematic review |
| title_fullStr | Effects of probiotics and its fermented milk on constipation: a systematic review |
| title_full_unstemmed | Effects of probiotics and its fermented milk on constipation: a systematic review |
| title_short | Effects of probiotics and its fermented milk on constipation: a systematic review |
| title_sort | effects of probiotics and its fermented milk on constipation a systematic review |
| topic | Constipation Probiotics Fermented milk Meta-analysis Dosage form |
| url | http://www.sciencedirect.com/science/article/pii/S2213453023000769 |
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