Predictive value of monocyte-to-high-density lipoprotein-cholesterol ratio (MHR) for poor prognosis after intravenous thrombolytic therapy for acute ischaemic stroke
Introduction The purpose of this study was to examine the relationship between monocyte-to-high-density lipoprotein-cholesterol ratio (MHR) and poor short-term 3-month and long-term 6-month prognosis after intravenous thrombolysis in patients with acute ischaemic stroke. Material and methods By ret...
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Termedia Publishing House
2024-05-01
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| Series: | Archives of Medical Science |
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| Online Access: | https://www.archivesofmedicalscience.com/Predictive-value-of-monocyte-to-high-density-lipoprotein-cholesterol-ratio-MHR-for,178013,0,2.html |
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| author | Yinglei Li Lingyun Xi Litao Li |
| author_facet | Yinglei Li Lingyun Xi Litao Li |
| author_sort | Yinglei Li |
| collection | DOAJ |
| description | Introduction
The purpose of this study was to examine the relationship between monocyte-to-high-density lipoprotein-cholesterol ratio (MHR) and poor short-term 3-month and long-term 6-month prognosis after intravenous thrombolysis in patients with acute ischaemic stroke.
Material and methods
By retrospective analysis, 763 eligible patients with acute ischaemic stroke with intravenous thrombolysis were included in the study, and the general data and clinical laboratory examination results of the patients were collected. The relationship between MHR and poor prognosis at 3 and 6 months in patients with intravenous thrombolysis was derived by stepwise regression using the R language, followed by 1:1 propensity score matching to determine the MHR threshold and to investigate the relationship between high and low MHR values and poor prognosis.
Results
MHR level was found to predict the prognosis of intravenous thrombolysis patients with acute ischaemic stroke, and it was an effective predictor of poor prognosis at 3 and 6 months after intravenous thrombolysis. MHR has a threshold of 0.584. High MHR levels were strongly associated with a poor 3-month prognosis of intravenous thrombolysis in patients with acute ischaemic stroke (OR = 5.657; 95% CI: 4.124–7.762; p < 0.001). High MHR level was closely associated with poor prognosis of acute ischaemic stroke patients with intravenous thrombolysis at 6 months (OR = 4.923; 95% CI: 3.603–6.726; p < 0.001).
Conclusions
MHR level is a valid predictor for poor prognosis at 3-6 months after intravenous thrombolysis in patients in acute ischaemic stroke. |
| format | Article |
| id | doaj-art-a4a62ea955c8404695c76e585c08e5b7 |
| institution | Kabale University |
| issn | 1734-1922 1896-9151 |
| language | English |
| publishDate | 2024-05-01 |
| publisher | Termedia Publishing House |
| record_format | Article |
| series | Archives of Medical Science |
| spelling | doaj-art-a4a62ea955c8404695c76e585c08e5b72025-01-27T10:45:12ZengTermedia Publishing HouseArchives of Medical Science1734-19221896-91512024-05-012061809182110.5114/aoms/178013178013Predictive value of monocyte-to-high-density lipoprotein-cholesterol ratio (MHR) for poor prognosis after intravenous thrombolytic therapy for acute ischaemic strokeYinglei Li0Lingyun Xi1Litao Li2Emergency Medicine, Baoding N0.1 Central Hospital, Baoding, ChinaLaboratory Medicine, Chinese People’s Liberation Army 82nd Army Group Hospital, Baoding, ChinaDepartment of Neurology, Hebei General Hospital, Shijiazhuang, ChinaIntroduction The purpose of this study was to examine the relationship between monocyte-to-high-density lipoprotein-cholesterol ratio (MHR) and poor short-term 3-month and long-term 6-month prognosis after intravenous thrombolysis in patients with acute ischaemic stroke. Material and methods By retrospective analysis, 763 eligible patients with acute ischaemic stroke with intravenous thrombolysis were included in the study, and the general data and clinical laboratory examination results of the patients were collected. The relationship between MHR and poor prognosis at 3 and 6 months in patients with intravenous thrombolysis was derived by stepwise regression using the R language, followed by 1:1 propensity score matching to determine the MHR threshold and to investigate the relationship between high and low MHR values and poor prognosis. Results MHR level was found to predict the prognosis of intravenous thrombolysis patients with acute ischaemic stroke, and it was an effective predictor of poor prognosis at 3 and 6 months after intravenous thrombolysis. MHR has a threshold of 0.584. High MHR levels were strongly associated with a poor 3-month prognosis of intravenous thrombolysis in patients with acute ischaemic stroke (OR = 5.657; 95% CI: 4.124–7.762; p < 0.001). High MHR level was closely associated with poor prognosis of acute ischaemic stroke patients with intravenous thrombolysis at 6 months (OR = 4.923; 95% CI: 3.603–6.726; p < 0.001). Conclusions MHR level is a valid predictor for poor prognosis at 3-6 months after intravenous thrombolysis in patients in acute ischaemic stroke.https://www.archivesofmedicalscience.com/Predictive-value-of-monocyte-to-high-density-lipoprotein-cholesterol-ratio-MHR-for,178013,0,2.htmlprognosisstrokeintravenous thrombolysismonocyte-to-high-density lipoprotein-cholesterol ratio |
| spellingShingle | Yinglei Li Lingyun Xi Litao Li Predictive value of monocyte-to-high-density lipoprotein-cholesterol ratio (MHR) for poor prognosis after intravenous thrombolytic therapy for acute ischaemic stroke Archives of Medical Science prognosis stroke intravenous thrombolysis monocyte-to-high-density lipoprotein-cholesterol ratio |
| title | Predictive value of monocyte-to-high-density lipoprotein-cholesterol ratio (MHR) for poor prognosis after intravenous thrombolytic therapy for acute ischaemic stroke |
| title_full | Predictive value of monocyte-to-high-density lipoprotein-cholesterol ratio (MHR) for poor prognosis after intravenous thrombolytic therapy for acute ischaemic stroke |
| title_fullStr | Predictive value of monocyte-to-high-density lipoprotein-cholesterol ratio (MHR) for poor prognosis after intravenous thrombolytic therapy for acute ischaemic stroke |
| title_full_unstemmed | Predictive value of monocyte-to-high-density lipoprotein-cholesterol ratio (MHR) for poor prognosis after intravenous thrombolytic therapy for acute ischaemic stroke |
| title_short | Predictive value of monocyte-to-high-density lipoprotein-cholesterol ratio (MHR) for poor prognosis after intravenous thrombolytic therapy for acute ischaemic stroke |
| title_sort | predictive value of monocyte to high density lipoprotein cholesterol ratio mhr for poor prognosis after intravenous thrombolytic therapy for acute ischaemic stroke |
| topic | prognosis stroke intravenous thrombolysis monocyte-to-high-density lipoprotein-cholesterol ratio |
| url | https://www.archivesofmedicalscience.com/Predictive-value-of-monocyte-to-high-density-lipoprotein-cholesterol-ratio-MHR-for,178013,0,2.html |
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